http://www.freshpatents.com/Chemistry--molecular-biology-and-microbiology-dtnewntc435.php USPTO Class 435 - Chemistry: molecular biology and microbiology en-us Mon, 14 May 2012 13:34:10 -0700 1000 Wednesday Thursday Friday Saturday Sunday 141 31 http://www.freshpatents.com/index.php?rss=true http://www.freshpatents.com/images/freshpatentsnav_rss.gif http://www.freshpatents.com/-dt20120510ptan20120115124.php Mon, 14 May 2012 13:34:10 -0700 A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon... http://www.freshpatents.com/-dt20120510ptan20120115125.php Mon, 14 May 2012 13:34:10 -0700 Method of detecting HIV-1 nucleic acids using nucleic acid amplification and a molecular torch hybridization probe. The invented method is characterized by high levels of precision in the quantitation of HIV-1 targets at low copy numbers, and by accurate detection of different HIV-1 subtypes, including M group and O group... http://www.freshpatents.com/-dt20120510ptan20120115126.php Mon, 14 May 2012 13:34:10 -0700 Disclosed are oligonucleotide amplification primers and detection probes specific for the amplification and detection of pathogenic organisms, including for example, specific Influenza A H1N1 viral isolates. Also disclosed is a biological organism identification kit including the disclosed nucleic acid probes and primers, as well as thermal cycling reagents that is... http://www.freshpatents.com/-dt20120510ptan20120115129.php Mon, 14 May 2012 13:34:10 -0700 Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least... http://www.freshpatents.com/-dt20120510ptan20120115130.php Mon, 14 May 2012 13:34:10 -0700 A target cell detection method includes performing a test measurement on a dispersion to obtain a measurement result 1, the test measurement being an optical or electromagnetic measurement, and the dispersion including labeled particles and target cells, the labeled particles being particles on each of which a substance that specifically... http://www.freshpatents.com/-dt20120510ptan20120115127.php Mon, 14 May 2012 13:34:10 -0700 The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... http://www.freshpatents.com/-dt20120510ptan20120115128.php Mon, 14 May 2012 13:34:10 -0700 The present invention is related to methods of detecting protein-protein interactions in living cells, as well as detecting the formation and/or inhibition of protein-protein interactions in cells.... http://www.freshpatents.com/-dt20120510ptan20120115133.php Mon, 14 May 2012 13:34:10 -0700 The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.... http://www.freshpatents.com/-dt20120510ptan20120115144.php Mon, 14 May 2012 13:34:10 -0700 This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection tumor-associated DNA, and to those methods of detecting and monitoring tumor-associated DNA found in the plasma or serum... http://www.freshpatents.com/-dt20120510ptan20120115142.php Mon, 14 May 2012 13:34:10 -0700 A method for zygosity analysis of the cotton Cry1Ac event 3006-210-23 is provided. The method provides 3006-210-23 event-specific and cotton-genome-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding.... http://www.freshpatents.com/-dt20120510ptan20120115141.php Mon, 14 May 2012 13:34:10 -0700 A method for zygosity analysis of the cotton Cry1F event 281-24-236 is provided. The method provides 281-24-236 event-specific and cotton endogenous reference gene-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding.... http://www.freshpatents.com/-dt20120510ptan20120115131.php Mon, 14 May 2012 13:34:10 -0700 The invention comprises methods for identifying mutations within the 3′ UTRs of genes that lead to increased risk or probability of developing cancer.... http://www.freshpatents.com/-dt20120510ptan20120115132.php Mon, 14 May 2012 13:34:10 -0700 The present invention is directed to methods of centromere discovery using centromere-associated proteins in a variety of experimental formats. The methods of the invention can be used on any organism, and include using Cal1, Cbf1, Cbf3, Cbf5, CenH3 (Cenp-A), Cenp-B, Cenp-C, Cenp-D, Cenp-E, Cenp-F, Cenp-G, Cenp-H, Cenp-I, Cenp-K, Cenp-L, Cenp-M,... http://www.freshpatents.com/-dt20120510ptan20120115135.php Mon, 14 May 2012 13:34:10 -0700 A method for site-specific detection and early diagnosis of periodontal disease using periodontal pocket fluid biomarkers is disclosed.... http://www.freshpatents.com/-dt20120510ptan20120115139.php Mon, 14 May 2012 13:34:10 -0700 Provided is a cancer evaluation method using a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject. At least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as the novel cancer marker in cancer evaluation. The... http://www.freshpatents.com/-dt20120510ptan20120115138.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a method and kit for in vitro diagnosing a complex disease such as cancer, in particular, acute myeloid leukemia (AML), colon cancer, kidney cancer, prostate cancer; transient ischemic attack (TIA), ischemia, in particular stroke, hypoxia, hypoxic-ischemic encephalopathy, perinatal brain damage, hypoxic-ischemic encephalopathy of neotatals asphyxia;... http://www.freshpatents.com/-dt20120510ptan20120115151.php Mon, 14 May 2012 13:34:10 -0700 The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises: analyzing a biological sample from said subject for detecting the presence of a p53 isoform selected from the group consisting of Δ133p53, Δ133p53γ and Δ133p53β, the presence of said... http://www.freshpatents.com/-dt20120510ptan20120115146.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a method for analyzing genetically abnormal cells including (a) preparing a cell sample containing eukaryotic cells, (b) conducting an antigen-antibody reaction to cells contained in the cell sample using antibodies which specifically bind to a molecule existing on the cell surface of eukaryotic cells after... http://www.freshpatents.com/-dt20120510ptan20120115134.php Mon, 14 May 2012 13:34:10 -0700 We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have... http://www.freshpatents.com/-dt20120510ptan20120115137.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates generally to methods for predicting progression, initiation and susceptibility of osteoarthritis in human subjects using their genotype test results.... http://www.freshpatents.com/-dt20120510ptan20120115150.php Mon, 14 May 2012 13:34:10 -0700 The invention refers to diagnosis and therapy of muscle degenerative disorders, as Duchenne Muscular Dystrophy (DMD) by means of a class of specific miRNAs.... http://www.freshpatents.com/-dt20120510ptan20120115140.php Mon, 14 May 2012 13:34:10 -0700 The present invention includes a rapid, selective, and accurate method of diagnosing a human subject with a triplet repeat genetic disorder of the FMR1 gene that leads to fragile X syndrome. The present invention also includes a rapid, selective, and accurate method of diagnosing a human subject at risk for... http://www.freshpatents.com/-dt20120510ptan20120115147.php Mon, 14 May 2012 13:34:10 -0700 Methods and reports for presenting genetic information that is patient-specific and relevant to treatment of neuropsychiatric disorders, including treatment resistant depression. The methods and reports described include genotype information for each of six specific genetic loci and allow patient-specific therapy for the effective treatment of treatment resistant disorders (TRD).... http://www.freshpatents.com/-dt20120510ptan20120115136.php Mon, 14 May 2012 13:34:10 -0700 The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities.... http://www.freshpatents.com/-dt20120510ptan20120115148.php Mon, 14 May 2012 13:34:10 -0700 This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.... http://www.freshpatents.com/-dt20120510ptan20120115152.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to clinical diagnosis of Alzheimer's disease or early-stage Alzheimer's disease in the live patient. In particular, the invention provides a screening method which can be used to assist with diagnosis of Alzheimer's disease in live human subjects, or to identify human subjects with a predisposition to... http://www.freshpatents.com/-dt20120510ptan20120115149.php Mon, 14 May 2012 13:34:10 -0700 The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the... http://www.freshpatents.com/-dt20120510ptan20120115145.php Mon, 14 May 2012 13:34:10 -0700 The present invention is directed to the use of the strand displacement activity of a modified polymerase. The present invention is more specifically directed to a modified Taq DNA polymerase, which exhibits strand displacement activity, whereas the native polymerase does not possess the strand displacement activity.... http://www.freshpatents.com/-dt20120510ptan20120115143.php Mon, 14 May 2012 13:34:10 -0700 Reagents and methods are provided for detecting the presence of a target polynucleotide in a sample are disclosed. In one aspect, a method for producing a labeled amplification product by amplifying a target nucleic acid sequence to produce an amplification product comprising the target sequence, a first probe-binding sequence 5′... http://www.freshpatents.com/-dt20120510ptan20120115153.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a marker for the prognosis of liver cancer; a composition for estimating the prognosis of liver cancer, which contains a substance for detecting a change in the expression level of the prognostic marker for liver cancer; a kit for estimating the prognosis of liver cancer,... http://www.freshpatents.com/-dt20120510ptan20120115155.php Mon, 14 May 2012 13:34:10 -0700 Disclosed is a nucleic acid amplification method which is based on a new principle and enables to amplify a nucleic acid having a specific nucleotide sequence in a simple manner, within a short time and with efficiency. The nucleic acid amplification method comprises the steps of: (a) obtaining a linear... http://www.freshpatents.com/-dt20120510ptan20120115154.php Mon, 14 May 2012 13:34:10 -0700 DNA oligomers comprising sequences that are absent from the genome of one or more organisms of interest are used as reference markers (RMs). The RMs are added to biological samples to “tag” and subsequently identify the samples as authentic and to distinguish tagged samples from samples obtained without said markers,... http://www.freshpatents.com/-dt20120510ptan20120115157.php Mon, 14 May 2012 13:34:10 -0700 The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.... http://www.freshpatents.com/-dt20120510ptan20120115156.php Mon, 14 May 2012 13:34:10 -0700 Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was... http://www.freshpatents.com/-dt20120510ptan20120115158.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a method of predicting the likelihood of embryo or oocyte survival. This method involves providing a sample of an embryo, an oocyte, or surrounding liquid or cells, and screening the sample for ceramidase expression or activity. The ceramidase expression or activity obtained through said screening... http://www.freshpatents.com/-dt20120510ptan20120115159.php Mon, 14 May 2012 13:34:10 -0700 The present invention provides a blood analyzer and a blood analyzing method capable of obtaining information regarding B lymphocytes and T lymphocytes without using a fluorescence-labeled antibody. The blood analyzer of the present invention includes a blood specimen supplying portion, a sample preparation portion that prepares a measurement sample without... http://www.freshpatents.com/-dt20120510ptan20120115162.php Mon, 14 May 2012 13:34:10 -0700 Antibodies that specifically bind to fatty acid amide hydrolases and methods of using the antibodies are provided herein.... http://www.freshpatents.com/-dt20120510ptan20120115161.php Mon, 14 May 2012 13:34:10 -0700 Serum-containing and serum-free immunoglobulin inhibitors of steroid hormone responsive cancer cell growth are disclosed, along with their methods of production. Also disclosed are defined cell culture media, assay protocols, and model systems using the inhibitors for demonstrating steroid hormone growth effects of natural and synthetic substances, and other cell culture... http://www.freshpatents.com/-dt20120510ptan20120115164.php Mon, 14 May 2012 13:34:10 -0700 Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.... http://www.freshpatents.com/-dt20120510ptan20120115163.php Mon, 14 May 2012 13:34:10 -0700 A method for the assay of the circulating extracellular portion of the IRAP protein (“insulin responsive aminopeptidase”) includes at least one stage of quantitative assay of the purified, secreted, extracellular portion of IRAP, via at least one labelled peptide, the labelled peptide interacting specifically with the extracellular portion of IRAP.... http://www.freshpatents.com/-dt20120510ptan20120115160.php Mon, 14 May 2012 13:34:10 -0700 The present application relates to the isolation and analysis of populations of microvesicles, such as populations of microvesicles that are shed by tumor cells and contain the protein ARF6. Invasive microvesicles from tumor cells contain a variety of specific proteins, including ARF6.... http://www.freshpatents.com/-dt20120510ptan20120115167.php Mon, 14 May 2012 13:34:10 -0700 A method for isolating a target bioentity from a biological sample, comprises contacting the biological sample with a magnetically-labelled ligand having selective binding affinity for the target bioentity, or for a determinant on the target bioentity, to form a target bioentity/labelled ligand complex, locating a separation module having a defined... http://www.freshpatents.com/-dt20120510ptan20120115165.php Mon, 14 May 2012 13:34:10 -0700 Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.... http://www.freshpatents.com/-dt20120510ptan20120115166.php Mon, 14 May 2012 13:34:10 -0700 The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD,... http://www.freshpatents.com/-dt20120510ptan20120115168.php Mon, 14 May 2012 13:34:10 -0700 The invention provides a bioassay for detection of Mycobacterium tuberculosis infection comprising artificially modified peptide subsequences of the T-cell epitope from M. tuberculosis Ag85B. Particularly preferred peptides have the form: SGGNNSPAX (SEQ ID 26), where X is Methionine (SEQ ID 18), Leucine (SEQ ID 17), Alanine (SEQ ID 15) or... http://www.freshpatents.com/-dt20120510ptan20120115173.php Mon, 14 May 2012 13:34:10 -0700 The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the renin-angiotensin system in a sample taken from a subject. Similarly, aberrant post-translational modification of the proteins or polypeptides as... http://www.freshpatents.com/-dt20120510ptan20120115169.php Mon, 14 May 2012 13:34:10 -0700 Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol,... http://www.freshpatents.com/-dt20120510ptan20120115171.php Mon, 14 May 2012 13:34:10 -0700 The invention relates to a method for diagnosing thrombophilia in a subject suffering from HIV or from a systemic auto-immune disease, said method comprising determining in a blood sample obtained from said subject the level of free Protein S having Activated Protein C (APC) cofactor activity and the level of... http://www.freshpatents.com/-dt20120510ptan20120115172.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are... http://www.freshpatents.com/-dt20120510ptan20120115170.php Mon, 14 May 2012 13:34:10 -0700 Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood... http://www.freshpatents.com/-dt20120510ptan20120115174.php Mon, 14 May 2012 13:34:10 -0700 A method aiding the diagnosis of interstitial cystitis involving the combination of an infection marker and an inflammation marker. More specifically, the method includes correlating the presence of urinary trypsin inhibitors in urine with the absence of traditional infection markers in urine to aid in the diagnosis of interstitial cystitis.... http://www.freshpatents.com/-dt20120510ptan20120115175.php Mon, 14 May 2012 13:34:10 -0700 The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a biological sample from the subject.... http://www.freshpatents.com/-dt20120510ptan20120115176.php Mon, 14 May 2012 13:34:10 -0700 The invention can be used in the search for new medicaments and new taste modulators. (c) selecting the test compound as a modulating compound if a difference in FRET signal in the absence and in the presence of test compound is measured in step (b).... http://www.freshpatents.com/-dt20120510ptan20120115177.php Mon, 14 May 2012 13:34:10 -0700 Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock.... http://www.freshpatents.com/-dt20120510ptan20120115179.php Mon, 14 May 2012 13:34:10 -0700 A flexible, thin, elongated band is used as a substrate. Similarly to a magnetic tape, the band is unwound from a feed reel and is transported past an outlet opening of a receptacle containing the cells such that the cells are poured onto the band. Subsequently, the band containing the... http://www.freshpatents.com/-dt20120510ptan20120115178.php Mon, 14 May 2012 13:34:10 -0700 Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser... http://www.freshpatents.com/-dt20120510ptan20120115180.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to an in vitro and/or ex vivo method of screening probiotic bacterial strains. The present invention also relates to a method of assessing quality of probiotic culture. In addition, the present invention relates to use of animal cells in screening of a probiotic strain. The present... http://www.freshpatents.com/-dt20120510ptan20120115183.php Mon, 14 May 2012 13:34:10 -0700 A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference... http://www.freshpatents.com/-dt20120510ptan20120115182.php Mon, 14 May 2012 13:34:10 -0700 The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from blood-stream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins... http://www.freshpatents.com/-dt20120510ptan20120115184.php Mon, 14 May 2012 13:34:10 -0700 A mastitis sensor and a method for detection of mastitis and determination of milk quality in real time (on-line). Methods and apparatuses for the rapid non-invasive determination of the concentration of dissolved molecular oxygen in milked milk are disclosed. Mastitis sensors are disclosed that include a fiberoptic, amperometric or potentiometric... http://www.freshpatents.com/-dt20120510ptan20120115181.php Mon, 14 May 2012 13:34:10 -0700 A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated... http://www.freshpatents.com/-dt20120510ptan20120115185.php Mon, 14 May 2012 13:34:10 -0700 A device for recovering biogas, comprising at least one fermenter (13) and a percolate tank (10) for collecting the percolate removed from the fermenter or fermenters (13). The percolate tank (10) has a percolate inlet (10c) that can be connected to an outlet of the fermenter or fermenters (13) and... http://www.freshpatents.com/-dt20120510ptan20120115186.php Mon, 14 May 2012 13:34:10 -0700 wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose. b) recovery of the fermentation product, a) fermentation of the sugar composition in the presence of a... http://www.freshpatents.com/-dt20120510ptan20120115187.php Mon, 14 May 2012 13:34:10 -0700 Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b) a prototrophy-restoring enzyme in a host cell that is auxotrophic for at least one metabolite. In various embodiments, the host cell is auxotrophic for a nitrogenous base... http://www.freshpatents.com/-dt20120510ptan20120115188.php Mon, 14 May 2012 13:34:10 -0700 The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same.... http://www.freshpatents.com/-dt20120510ptan20120115190.php Mon, 14 May 2012 13:34:10 -0700 Systems and methods for air cooling a microfluidic device using confinement channels to isolate cooling air from exposed liquids are disclosed. The systems and methods may also thermally condition the cooling airflow for improved robustness of the microfluidic device. In one embodiment, the air cooling system includes a split-level cooling... http://www.freshpatents.com/-dt20120510ptan20120115189.php Mon, 14 May 2012 13:34:10 -0700 The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves... http://www.freshpatents.com/-dt20120510ptan20120115191.php Mon, 14 May 2012 13:34:10 -0700 There is provided a new strain, that is Aspergillus fumigatus, MTCC 5453, and its use in the production of fructo-oligosaccharide. The invention also provides an efficient, rapid and method for increased production of fructo-oligosaccharide by using the strain Aspergillus fumigatus MTCC 5453.... http://www.freshpatents.com/-dt20120510ptan20120115192.php Mon, 14 May 2012 13:34:10 -0700 A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher... http://www.freshpatents.com/-dt20120510ptan20120115193.php Mon, 14 May 2012 13:34:10 -0700 The present invention includes a system and method for making a biofuel comprising: providing a nitrogen-limiting, minimal growth media comprising glycerol, sugars generated from cellulosic biomass or both, under conditions in which an oleaginous microbe converts the growth media into at least one of triacylglycerol, neutral lipids, fatty acids, long-chain... http://www.freshpatents.com/-dt20120510ptan20120115194.php Mon, 14 May 2012 13:34:10 -0700 The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or... http://www.freshpatents.com/-dt20120510ptan20120115195.php Mon, 14 May 2012 13:34:10 -0700 The invention provides consolidated bioprocessing methods and host cells. The host cells are capable of directly converting biomass polymers or sunlight into biodiesel equivalents and other fatty acid derivatives. In particular, the invention provides a method for producing biodiesel equivalents and other fatty acid derivatives from a biomass polymer including... http://www.freshpatents.com/-dt20120510ptan20120115196.php Mon, 14 May 2012 13:34:10 -0700 at least one of the genes being endogenous, and at least one of the genes being exogenous, efficiently produces isobutanol. (5) a gene which encodes an enzyme having alcohol dehydrogenase activity, (4) a gene which encodes an enzyme having 2-keto acid decarboxylase activity; and... http://www.freshpatents.com/-dt20120510ptan20120115197.php Mon, 14 May 2012 13:34:10 -0700 Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.... http://www.freshpatents.com/-dt20120510ptan20120115198.php Mon, 14 May 2012 13:34:10 -0700 A stable continuous method for producing ethanol from anaerobic fermentation of a gaseous substrate containing at least one reducing gas in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This... http://www.freshpatents.com/-dt20120510ptan20120115200.php Mon, 14 May 2012 13:34:10 -0700 A continuous process for the recovery of ethanol from hemicellulose and cellulose from lignocellulosic biomass. Yield of fermentable sugars can be maximized by continuous operation of the pre-treatment system and careful selection of pretreatment conditions including the addition of only small amounts of dilute mineral acid and low pressure. With... http://www.freshpatents.com/-dt20120510ptan20120115199.php Mon, 14 May 2012 13:34:10 -0700 A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing treated basidiomycota mycelia and/or yeast cells to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation... http://www.freshpatents.com/-dt20120510ptan20120115201.php Mon, 14 May 2012 13:34:10 -0700 Systems and methods for capture and sequestration of CO2, SOx, NOx, and/or other compounds present in industrial waste streams and use of the captured waste as a nutrient source to support a microbial population. The microbial population can use the nutrients from the industrial waste stream and an energy source... http://www.freshpatents.com/-dt20120510ptan20120115202.php Mon, 14 May 2012 13:34:10 -0700 A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.... http://www.freshpatents.com/-dt20120510ptan20120115203.php Mon, 14 May 2012 13:34:10 -0700 A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.... http://www.freshpatents.com/-dt20120510ptan20120115204.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).... http://www.freshpatents.com/-dt20120510ptan20120115205.php Mon, 14 May 2012 13:34:10 -0700 The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate... http://www.freshpatents.com/-dt20120510ptan20120115206.php Mon, 14 May 2012 13:34:10 -0700 The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for... http://www.freshpatents.com/-dt20120510ptan20120115207.php Mon, 14 May 2012 13:34:10 -0700 The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b)... http://www.freshpatents.com/-dt20120510ptan20120115208.php Mon, 14 May 2012 13:34:10 -0700 The invention is directed to methods, kits and compositions using specially designed nucleic acid components for efficient assembly of a DNA construct. The method involves a) incubating a support with a first form of nucleic acid components under conditions to form support-bound nucleic acid component complexes; b) removing unbound first... http://www.freshpatents.com/-dt20120510ptan20120115209.php Mon, 14 May 2012 13:34:10 -0700 The present invention thus aims to propose a bioreactor which has an improved yield (concentration, productivity), which is capable of culturing microorganisms sensitive to mechanical stresses, and which is energy-saving. The subject matter of the invention is a method for culturing microorganisms in suspension in a culture medium, in which... http://www.freshpatents.com/-dt20120510ptan20120115210.php Mon, 14 May 2012 13:34:10 -0700 A novel waterborne cultivator, which provides the benefits of known systems for culture of photosynthetic micro-organisms in a novel configuration, incorporating a simplified, two-phase rotary mixing and gas injection system, the two phases being liquid and gas (CO2). The mixing system provides optimum growth conditions through increased turbulent vertical mixing... http://www.freshpatents.com/-dt20120510ptan20120115211.php Mon, 14 May 2012 13:34:10 -0700 Apparatus for testing the quality of a fluid sample comprising a body defining an interior space including a primary chamber and one or more secondary chambers, the apparatus having a first configuration in which it is arranged to hold at least some of the fluid sample in the primary chamber... http://www.freshpatents.com/-dt20120510ptan20120115212.php Mon, 14 May 2012 13:34:10 -0700 A non-instrumented biochemical assay device, such as a device for the processing of clinical specimens for molecular diagnostic applications. In one embodiment, an assay device comprises a lid which covers a reagent tube, which is disposed on a base. The platform utilizes chemical heating and optional temperature modulation by phase... http://www.freshpatents.com/-dt20120510ptan20120115214.php Mon, 14 May 2012 13:34:10 -0700 An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays... http://www.freshpatents.com/-dt20120510ptan20120115213.php Mon, 14 May 2012 13:34:10 -0700 The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis... http://www.freshpatents.com/-dt20120510ptan20120115216.php Mon, 14 May 2012 13:34:10 -0700 A multi-compartment resealable container for testing for the presence of micro-organisms is provided with or adapted to receive a sample in a first substantially rigid transparent compartment, a growth medium in a second compartment, and a sanitizer in a third compartment, the compartments being separated by foil seals, the second... http://www.freshpatents.com/-dt20120510ptan20120115215.php Mon, 14 May 2012 13:34:10 -0700 A light source reflector includes a structure having three or more internal reflective surfaces defining a first light entry aperture and a second light exit aperture having an area that is greater than the area of the entry aperture. A single light source, or a plurality of uniformly distributed light... http://www.freshpatents.com/-dt20120510ptan20120115217.php Mon, 14 May 2012 13:34:10 -0700 A device and system for growing a photosynthetic culture is provided which employs one or a plurality of vertically disposed photopanels having interior cavities configured for holding liquid and the photosynthetic culture such as algae. The inner chamber of the photopanels may have a shape that is structurally supported by... http://www.freshpatents.com/-dt20120510ptan20120115218.php Mon, 14 May 2012 13:34:10 -0700 The invention relates to a bioreactor (1) comprising a reactor vessel (41) having a mixing chamber (3) separated by a partition (44) from a reaction chamber (2) located generally above the mixing chamber (3), the mixing chamber (3) having an inlet system (4) for influent or a mixture of influent... http://www.freshpatents.com/-dt20120510ptan20120115220.php Mon, 14 May 2012 13:34:10 -0700 The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.... http://www.freshpatents.com/-dt20120510ptan20120115219.php Mon, 14 May 2012 13:34:10 -0700 Use of a polynucleotide encoding or a polypeptide comprising at least the extra-cellular IPT-3 and IPT-4 domains of hepatocyte growth factor receptor for the screening and/or development of pharmacologically active agents useful in the treatment of cancer, preferably a cancer with dysregulation of hepatocyte growth factor receptor.... http://www.freshpatents.com/-dt20120510ptan20120115221.php Mon, 14 May 2012 13:34:10 -0700 (B) a peptide which consists of an amino acid sequence comprising a substitution or addition of one or several amino acids with respect to the peptide consisting of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has capacity to induce... http://www.freshpatents.com/-dt20120510ptan20120115222.php Mon, 14 May 2012 13:34:10 -0700 Compositions and methods for the proliferation, differentiation, and maintenance of stem cells are described. Preferred are the use of hematopoietic stem cells in combination with a collagen matrix.... http://www.freshpatents.com/-dt20120510ptan20120115223.php Mon, 14 May 2012 13:34:10 -0700 Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a... http://www.freshpatents.com/-dt20120510ptan20120115224.php Mon, 14 May 2012 13:34:10 -0700 In a culture method of the present invention, by culturing bone marrow stromal cells or mesenchymal stem cells under a pseudo micro-gravity environment generated by multi-axis rotation, bone marrow stromal cells or mesenchymal stem cells having an average cell size smaller than that before the culture are obtained. The bone... http://www.freshpatents.com/-dt20120510ptan20120115226.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to the use of 3D culturing systems for the derivation of hepatocyte-like cells from human pluripotent stem cells (hPS). In particular, the invention concerns the directed differentiation and maturation of human pluripotent stem cells into hepatocyte like cells in 3D hollow fiber capillary bioreactors.... http://www.freshpatents.com/-dt20120510ptan20120115225.php Mon, 14 May 2012 13:34:10 -0700 Purified somatic cell reprogramming factors are described herein. The factors are particularly useful alone or in combination with at least one effector of cellular metabolism, in order to generate at least one reprogramming somatic cell. Methods for using at least one somatic cell reprogramming factor and at least one somatic... http://www.freshpatents.com/-dt20120510ptan20120115227.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site;... http://www.freshpatents.com/-dt20120510ptan20120115228.php Mon, 14 May 2012 13:34:10 -0700 Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA... http://www.freshpatents.com/-dt20120510ptan20120115229.php Mon, 14 May 2012 13:34:10 -0700 The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving... http://www.freshpatents.com/-dt20120510ptan20120115230.php Mon, 14 May 2012 13:34:10 -0700 Materials and methods for identifying lignin regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating lignin accumulation are also disclosed.... http://www.freshpatents.com/-dt20120510ptan20120115231.php Mon, 14 May 2012 13:34:10 -0700 The present invention provides novel lysophospholipid acyltransferases. The object of the present invention is attained by the nucleotide sequences of SEQ ID NOs: 1 and 6 and the amino acid sequences of SEQ ID NOs: 2 and 7 of the present invention.... http://www.freshpatents.com/-dt20120510ptan20120115232.php Mon, 14 May 2012 13:34:10 -0700 Provided is a system which can induce the degradation of a protein of interest in a mammalian cell system reliably and stably within a short time. A mammalian cell inducible for protein degradation, the degradation of a protein of interest being induced by an auxin, in which the mammalian cell... http://www.freshpatents.com/-dt20120510ptan20120115233.php Mon, 14 May 2012 13:34:10 -0700 The present invention relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation... http://www.freshpatents.com/-dt20120510ptan20120115234.php Mon, 14 May 2012 13:34:10 -0700 Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.... http://www.freshpatents.com/-dt20120510ptan20120115235.php Mon, 14 May 2012 13:34:10 -0700 The invention provides organisms and methods of using and making organisms with enhanced cellulase expression....