http://www.freshpatents.com/Drug-bio-affecting-and-body-treating-compositions-dtnewntc514.php USPTO Class 514 - Drug, bio-affecting and body treating compositions en-us Tue, 18 Aug 2009 22:49:05 -0700 1000 Wednesday Thursday Friday Saturday Sunday 141 31 http://www.freshpatents.com/index.php?rss=true http://www.freshpatents.com/images/freshpatentsnav_rss.gif http://www.freshpatents.com/Method-for-in-vitro-molecular-evolution-of-protein-function-dt20090813ptan20090203572.php Tue, 18 Aug 2009 22:49:05 -0700 The invention provides a method for generating a polynucleotide sequence or population of sequences from parent polynucleotide sequences, the method comprising the steps of (a) providing a first population of polynucleotide molecules and a second population of polynucleotide molecules, the first and second populations together constituting plus and minus strands... http://www.freshpatents.com/Method-for-modulating-hair-growth-dt20090813ptan20090203574.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to the use of Lhx2 as a target for modulating the hair growth. Screening assays for identifying agents which increase or decrease the expression or activity of Lhx2 are provided.... http://www.freshpatents.com/Targeted-therapeutic-proteins-dt20090813ptan20090203575.php Tue, 18 Aug 2009 22:49:05 -0700 Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor.... http://www.freshpatents.com/Use-of-dietary-fibres-against-muscle-wasting-dt20090813ptan20090203573.php Tue, 18 Aug 2009 22:49:05 -0700 A composition nutritional containing dietary fibres is useful for the treatment of muscle wasting, if the dietary fibre comprise at least 30 wt. % of galacto-oligosaccharides or other oligosaccharides having mainly anhydropyranose units, and having a chain length of 3-10 units. The composition may further contain other oligo- or polysaccharides,... http://www.freshpatents.com/Methods-and-compositons-for-pulmonary-delivery-of-insulin-dt20090813ptan20090203576.php Tue, 18 Aug 2009 22:49:05 -0700 Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar regions of the lungs.... http://www.freshpatents.com/Azepinoindole-derivatives-as-pharmaceutical-agents-dt20090813ptan20090203577.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.... http://www.freshpatents.com/Certain-crystalline-diphenylazetidinone-hydrates-pharmaceutical-compositions-thereof-and-methods-for-their-use-dt20090813ptan20090203578.php Tue, 18 Aug 2009 22:49:05 -0700 in which n has a value of from 0.5 to 1.8. The compound may be suitable, for example, as a hypolipidemic. Provided are certain crystalline hydrates of the formula I... http://www.freshpatents.com/Compositions-and-methods-of-use-for-alpha-1-antitrypsin-having-no-significant-serine-protease-inhibitor-activity-dt20090813ptan20090203580.php Tue, 18 Aug 2009 22:49:05 -0700 Embodiments herein illustrate methods and compositions for treating medical disorders. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating graft rejection, transplant rejection or diabetes in a subject. Other embodiments herein relate to compounds including naturally occurring and synthetic mutant compositions of alpha-1 antitrypsin, wherein the alpha-1... http://www.freshpatents.com/Glycopegylated-granulocyte-colony-stimulating-factor-dt20090813ptan20090203579.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action... http://www.freshpatents.com/Lysobactin-amides-dt20090813ptan20090203582.php Tue, 18 Aug 2009 22:49:05 -0700 The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.... http://www.freshpatents.com/Novel-peptides-for-use-in-the-treatment-of-obesity-dt20090813ptan20090203581.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the... http://www.freshpatents.com/Use-of-type-b-lantibiotic-based-compounds-having-antimicrobial-activity-dt20090813ptan20090203583.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides methods for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject, the method comprising administering to the subject a type-B lantibiotic. In particular, the invention provides methods for the treatment or prophylaxis of a Clostridium difficile infection. The... http://www.freshpatents.com/Peptide-based-compounds-dt20090813ptan20090203584.php Tue, 18 Aug 2009 22:49:05 -0700 The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.... http://www.freshpatents.com/Capreomycin-derivatives-and-their-use-as-antibacterials-dt20090813ptan20090203585.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to phenylurea derivatives of capreomycin I, IIB, IIA, or IB, and metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present invention are useful as antibacterial agents for treating bacterial infections and for treating disorders caused by bacterial infections. The present invention also... http://www.freshpatents.com/Abc-transporter-ligand-dt20090813ptan20090203598.php Tue, 18 Aug 2009 22:49:05 -0700 Compositions and methods of using scorpion venom peptide that is a ligand for ABC transporters. One aspect provides a peptide having at least 80% sequence identity to SEQ ID NO: 1. The peptide Is believed to have a molecular mass of about 3.7 kDa and specifically interacts with cystic fibrosis... http://www.freshpatents.com/Anti-microbial-defensin-related-peptides-and-methods-of-use-dt20090813ptan20090203611.php Tue, 18 Aug 2009 22:49:05 -0700 An antimicrobial peptide and its analogs that are insensitive to physiological salt and divalent cation concentrations is provided, as are methods for their use to treat and prevent bacterial infections. The peptides are especially useful to treat infections caused by bacteria that are resistant to traditional antibiotic therapy.... http://www.freshpatents.com/Anticancer-peptide-dt20090813ptan20090203594.php Tue, 18 Aug 2009 22:49:05 -0700 A polypeptide and methods of using the polypeptide for treating malignancy by administering to a subject a composition of the polypeptide. Pharmaceutical compositions of the polypeptide.... http://www.freshpatents.com/Chemically-modified-human-growth-hormone-receptor-antagonist-conjugates-dt20090813ptan20090203589.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides a chemically modified human Growth Hormone (hGH) receptor antagonists prepared by attaching a single polyethylene glycol moiety to the N-terminus. The chemically-modified protein according to the present invention have decreased PEGylation heterogeneity and which may also have increased binding affinity.... http://www.freshpatents.com/Compositions-and-methods-for-diagnosis-and-treatment-of-type-2-diabetes-dt20090813ptan20090203602.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates generally to the identification of biological markers associated with an increased risk of developing Diabetes, as well as methods of using such biological markers in diagnosis and prognosis of Diabetes. The biological markers of the invention may indicate new targets for therapy or constitute new therapeutics... http://www.freshpatents.com/Compositions-for-the-treatment-and-prevention-of-nephropathy-dt20090813ptan20090203603.php Tue, 18 Aug 2009 22:49:05 -0700 Compositions and methods for the prevention and treatment of nephropathy, including hypertensive and diabetic nephropathy, and nephropathy associated with insulin resistance and metabolic syndrome are described. Compositions of the invention include a compound that binds to a receptor for the glucagon like peptide-1, an incretin, a glucagon-like peptide-1 (GLP-1), an... http://www.freshpatents.com/Diagnosis-and-therapy-of-cell-proliferative-disorders-characterized-by-resistance-to-trail-induced-apoptosis-dt20090813ptan20090203587.php Tue, 18 Aug 2009 22:49:05 -0700 Described are methods and compounds for diagnosis and therapy of subsets of cell proliferative disorders which are characterized by resistance to TRAIL induced apoptosis. Examples of such diseases are B-cell chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and prostate cancer. Furthermore, methods for identifying drugs which are suitable for... http://www.freshpatents.com/Immunogenic-constructs-dt20090813ptan20090203593.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to molecules, which can be used to induce a therapeutic or prophylactic immune response against MAP. In particular, the present invention relates to polypeptides comprising an alipC polypeptide sequence, a gsd polypeptide sequence, a p12 polypeptide sequence and an mpa polypeptide sequence, wherein said ahpC polypeptide... http://www.freshpatents.com/Infant-nutrition-with-hydrolised-proteins-dt20090813ptan20090203592.php Tue, 18 Aug 2009 22:49:05 -0700 The invention concerns a method to treat and/or prevent childhood obesity comprising administering a nutritional composition containing fat, digestible carbohydrates and protein, wherein the protein comprises at least 25 wt. % peptides with a chain length of 25 to 30 amino acids based on dry weight of protein.... http://www.freshpatents.com/Method-and-compositions-for-simultaneously-regulating-memory-and-mood-dt20090813ptan20090203607.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention is concerned with methods and compositions for simultaneously treating or modulating memory and mood within the same individual.... http://www.freshpatents.com/Method-for-ameliorating-an-inflammatory-skin-condition-dt20090813ptan20090203586.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to the use of thioredoxin in the manufacture of a medicament suitable for application to a skin surface for ameliorating an inflammatory skin condition. The present invention further relates to a method of ameliorating an inflammatory skin condition comprising applying to a skin surface an effective... http://www.freshpatents.com/Method-for-the-inhibition-of-angiogenesis-dt20090813ptan20090203590.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention is based on the discovery that Matrilin-1 has antiangiogenic and anticancer properties. The invention is directed to a method of treating a disease that responds to an inhibition of angiogenesis. Additionally, the invention can be applied to those at risk for developing a disease that responds to... http://www.freshpatents.com/Method-for-the-treatment-of-neutropenia-by-administration-of-a-multi-pegylated-granulocyte-colony-stimulating-factor--g-csf--variant-dt20090813ptan20090203601.php Tue, 18 Aug 2009 22:49:05 -0700 The invention relates to a method for treating or preventing neutropenia in a patient receiving chemotherapy by administering a multi-PEGylated granulocyte colony stimulating factor (G-CSF) variant on the same day that chemotherapy is administered.... http://www.freshpatents.com/Methods-and-compositions-for-emergency-contraception-using-endothelin-receptor-antagonists-dt20090813ptan20090203591.php Tue, 18 Aug 2009 22:49:05 -0700 Disclosed are methods and compositions containing endothelin receptor antagonists for emergency contraception.... http://www.freshpatents.com/Methods-for-treating-a-condition-characterized-by-dysfunction-in-protein-homeostasis-dt20090813ptan20090203605.php Tue, 18 Aug 2009 22:49:05 -0700 Methods are provided for treating conditions characterized by dysfunction in protein homeostasis in a patient in need thereof. A method for treating a condition characterized by dysfunction in protein homeostasis in a patient in need thereof is provided which comprises administering to the patient a proteostasis regulator in an amount... http://www.freshpatents.com/Methods-of-treating-obesity-or-diabetes-using-nt-4-5-dt20090813ptan20090203610.php Tue, 18 Aug 2009 22:49:05 -0700 The invention concerns methods for treating obesity, non-insulin dependent diabetes mellitus, metabolic syndrome, and other related diseases by administering an NT-4/5 polypeptide. The invention also concerns compositions and kits comprising an NT-4/5 polypeptide.... http://www.freshpatents.com/Methods-to-restore-glycemic-control-dt20090813ptan20090203597.php Tue, 18 Aug 2009 22:49:05 -0700 Provided herein are methods and compositions to achieve a sustained delay in the progression of, or an amelioration of diabetes in a subject, or a delay in diabetes onset in a subject at risk for diabetes, comprising an abbreviated course of administration of a pharmaceutical composition comprising an exendin or... http://www.freshpatents.com/N-terminal-modified-peg-trail-method-for-preparing-and-uses-thereof-dt20090813ptan20090203599.php Tue, 18 Aug 2009 22:49:05 -0700 Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility... http://www.freshpatents.com/Neuregulin-variants-and-methods-of-screening-and-using-thereof-dt20090813ptan20090203595.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides polypeptide variants of neuregulin-1β (NRG-1β) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of screening and producing polypeptide variants of NRG-1β and methods of using polypeptide variants of NRG-1β for treating diseases.... http://www.freshpatents.com/Novel-proteins-and-use-thereof-dt20090813ptan20090203608.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides a novel secretory/membrane protein associated with adipocyte differentiation and/or metabolism function, specifically, an adipocyte-derived secretory/membrane protein containing amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16,... http://www.freshpatents.com/Outcome-prediction-and-risk-classification-in-childhood-leukemia-dt20090813ptan20090203588.php Tue, 18 Aug 2009 22:49:05 -0700 Genes and gene expression profiles useful for predicting outcome, risk classification, cytogenetics and/or etiology in pediatric acute lymphoblastic leukemia (ALL). OPAL1 is a novel gene associated with outcome and, along with other newly identified genes, represent a novel therapeutic targets.... http://www.freshpatents.com/Pharmaceutical-composition-for-the-prophylaxis-and-treatment-of-hiv-infection-and-its-use-dt20090813ptan20090203600.php Tue, 18 Aug 2009 22:49:05 -0700 Pharmaceutical compositions for the prophylaxis and treatment of HIV infection and its use are provided. Particularly, the present invention provides a pharmaceutical composition comprising anti-virus peptides, use of said composition for manufacturing a medicament for the prophylaxis and treatment of HIV infection, and method for preventing and treating HIV infection... http://www.freshpatents.com/Phosphatase-inhibitor-protein-1-as-a-regulator-of-cardiac-function-dt20090813ptan20090203596.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (1-1). In particular, the 1-1 mutant forms comprise altered phosphorylation sites of PKC-α. In addition, the present invention relates to methods of regulating cardiac contractility and function, and for treatment of cardio myopathy and... http://www.freshpatents.com/Soothing-agent-and-food-for-treating-fatigue-dt20090813ptan20090203604.php Tue, 18 Aug 2009 22:49:05 -0700 In accordance with the present invention, a soothing agent and/or a revitalizing agent containing protein hydrolysates obtained by degrading substrate protein via germinated soybean cotyledon-derived thiol protease and/or microorganism-derived serine protease are provided. It is an objective of the present invention to provide a soothing agent and a food for treating... http://www.freshpatents.com/Systems-and-methods-for-preparing-autologous-fibrin-glue-dt20090813ptan20090203613.php Tue, 18 Aug 2009 22:49:05 -0700 The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container... http://www.freshpatents.com/Systems-for-and-methods-of-use-of-therapeutic-nutrition-for-the-management-of-age-associated-and-age-specific-health-conditions-of-the-elderly-dt20090813ptan20090203606.php Tue, 18 Aug 2009 22:49:05 -0700 Nutritional compositions which provide for improved taste profiles for the elderly while simultaneously providing nutrition specific to assist in the management of nutritional deficiencies that lead to age specific and age associated health conditions in the elderly. There are also provided products using these compositions and incorporating packaging design, volume... http://www.freshpatents.com/Use-of-agents-that-prevent-the-generation-of-amyloid-like-proteins-and-or-drusen-and-or-use-of-agents-that-promote-sequestration-and-or-degradation-of-and-or-prevent-the-neurotoxic-effects-of-such-proteins-in-the-treatment-of-macular-degeneration-dt20090813ptan20090203614.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides compositions and methods for treating age-related macular degeneration (AMD). More specifically, the methods of the invention target amyloid proteins and drusen that tend to accumulate in the eyes of those patients suffering from AMD. AMD is treated in the methods of the invention by providing agents... http://www.freshpatents.com/Use-of-il-1-inhibitors-for-treating-il-1-mediated-diseases-dt20090813ptan20090203609.php Tue, 18 Aug 2009 22:49:05 -0700 The invention relates to methods for treating or preventing arthritis. The method comprises administering to patients in need thereof therapeutically effective amounts of an IL-1 inhibitor and methotrexate. In a preferred embodiment, the IL-1 inhibitor is human recombinant IL-1ra and the methotrexate is N-[4-[(2,4-diamino-6-pteridinyl)methylamino]benzoyl]-L-glutamic acid. The invention also relates to... http://www.freshpatents.com/Xenorhabdus-tc-proteins-and-genes-for-pest-control-dt20090813ptan20090203612.php Tue, 18 Aug 2009 22:49:05 -0700 The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used... http://www.freshpatents.com/Chimeric-peptides-for-the-regulation-of-gtpases-dt20090813ptan20090203617.php Tue, 18 Aug 2009 22:49:05 -0700 Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer.... http://www.freshpatents.com/Methods-for-treating-pain-and-screening-analgesic-compounds-dt20090813ptan20090203616.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to the use of compounds that block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) for treating pain, such as neuropathic pain and inflammatory pain, and inflammatory disorders, such as arthritis. The present invention also relates to screening compounds to identify analgesic agents that block... http://www.freshpatents.com/Use-of-activity-dependent-neurotrophic-factor-for-enhancing-learning-and-memory--pre-and-post-natal-administration-dt20090813ptan20090203615.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides methods for improving performance (e.g., learning and/or memory) using ADNF polypeptides, by treating the subject prenatally or postnatally with an Activity Dependent Neurotrophic Factor (ADNF) polypeptide in an amount sufficient to improve postnatal learning and/or memory of the subject.... http://www.freshpatents.com/Analog-compounds-of-analgesic-peptides-derived-from-the-venom-of-crotalus-durissus-terrificus-snakes-their-uses-compositions-methods-of-preparation-and-purification-dt20090813ptan20090203618.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention refers to analog compounds of peptides having the amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4, including analgesic peptides derived from snakes of species such as Crotalus durissus terrificus; their uses in the treatment, diagnosis... http://www.freshpatents.com/Artificial-platelets-dt20090813ptan20090203619.php Tue, 18 Aug 2009 22:49:05 -0700 Therapeutic agents suitable for use as artificial platelets are described. The agents comprise a fibrinogen binding precursor bound to an insoluble carrier, wherein the fibrinogen binding precursor can be converted by a wound site specific agent, such as thrombin, to a fibrinogen binding component bound to the carrier. The fibrinogen... http://www.freshpatents.com/Methods-for-attenuating-release-of-inflammatory-mediators-and-peptides-useful-therein-dt20090813ptan20090203620.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention includes methods of inhibiting or suppressing cellular secretory processes. More specifically the present invention relates to inhibiting or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from granules in inflammatory cells. In this regard, the... http://www.freshpatents.com/Alpha-fetoprotein-peptides-dt20090813ptan20090203624.php Tue, 18 Aug 2009 22:49:05 -0700 The invention relates to compounds that include peptides that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer.... http://www.freshpatents.com/Method-of-treating-metastatic-stage-prostate-cancer-dt20090813ptan20090203622.php Tue, 18 Aug 2009 22:49:05 -0700 The invention provides methods and dosing regimens for treating metastatic stage prostate cancer in a subject using degarelix, as well as related methods of using degarelix in a subject identified as having metastatic stage prostate cancer, and methods of using degarelix to prevent or delay the progression of locally advanced... http://www.freshpatents.com/Method-of-treating-prostate-cancer-with-gnrh-antagonist-dt20090813ptan20090203623.php Tue, 18 Aug 2009 22:49:05 -0700 The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.... http://www.freshpatents.com/Phage-display-selection-of-anti-fungal-peptides-dt20090813ptan20090203625.php Tue, 18 Aug 2009 22:49:05 -0700 A method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. Also provided are compositions containing peptides identified using the method of the present invention. In addition,... http://www.freshpatents.com/Tripeptides-that-down-regulate-the-activity-of-plasma-membrane-transporters-including-sodium-d-glucose-cotransporter-sglt1-dt20090813ptan20090203621.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification... http://www.freshpatents.com/Pediatric-amino-acid-solution-for-parenteral-nutrition-dt20090813ptan20090203626.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to an amino acid solution for the parenteral nutrition of pediatric patients. The amino acid solution provides for an increased concentration of glutamine, tyrosine, cysteine and taurine, while the concentrations of phenylalanine and methionine is small. Glutamine and tyrosine are provided in the form of oligopeptides.... http://www.freshpatents.com/Specific-binding-sites-in-collagen-for-integrins-and-use-thereof-dt20090813ptan20090203627.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods... http://www.freshpatents.com/Composition-method-and-kit-for-treating-skin-disorders-and-improving-skin-condition-dt20090813ptan20090203628.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention provides a composition, method and kit for treating skin disorders and improving skin condition. The composition, method and kit is particularly suited for treating acne vulgaris, seborrhea, rosacea, hirsutism, psoriasis, oily skin, dry skin, discoloration, post inflammatory hyper pigmentation, sun spots, and wrinkles.... http://www.freshpatents.com/Inhibitors-of-cathepsin-b-dt20090813ptan20090203629.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention is directed to a method of using compounds of Formula (I) to inhibit Cathepsin B. Specifically the compounds of the present invention are useful as therapeutic agents for the treatment of tumor invasion, metastasis, Alzheimer's Disease, arthritis, inflammatory diseases such as chronic and acute pancreatitis, inflammatory airway... http://www.freshpatents.com/Peptide-deformylase-inhibitors-as-novel-antibiotics-dt20090813ptan20090203631.php Tue, 18 Aug 2009 22:49:05 -0700 A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1′, P2′, and P3′, wherein P2′ connects P1′ and P3′, wherein P1′ and P3′ each have a side chain, and wherein the side chains on P1′ and P3′ are crosslinked to form the macrocyclic PDF... http://www.freshpatents.com/Process-for-preparing-atazanavir-bisulfate-and-novel-forms-dt20090813ptan20090203630.php Tue, 18 Aug 2009 22:49:05 -0700 A process is also provided for preparing atazanavir bisulfate as Pattern C material. A novel form of atazanavir bisulfate is also provided which is Form E3 which is a highly crystalline triethanolate solvate of the bisulfate salt from ethanol. A process is provided for preparing the HIV protease inhibitor atazanavir bisulfate... http://www.freshpatents.com/Compositions-and-methods-for-treating-contracture-dt20090813ptan20090203632.php Tue, 18 Aug 2009 22:49:05 -0700 A method for treating contracture is provided that includes administering to a patient in need thereof a composition that includes a therapeutic agent effective in treating contracture. Compositions, devices, and kits for use in treating contracture are also described.... http://www.freshpatents.com/Pyrazole-derivatives-medicinal-composition-containing-the-same-medicinal-use-thereof-and-intermediate-for-production-thereof-dt20090813ptan20090203633.php Tue, 18 Aug 2009 22:49:05 -0700 while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents an optionally substituted C1-6 alkylene group etc.; Z represents —RB, —CORC etc. in which RB... http://www.freshpatents.com/Compositions-and-uses-of-amooranin-compounds-dt20090813ptan20090203634.php Tue, 18 Aug 2009 22:49:05 -0700 Amooranin (AMR) has been found to cause tumor cell death through G2/M cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR compounds, including AMR analogs, can be used in the treatment of a number of... http://www.freshpatents.com/Hxaaa01-polynucleotides-dt20090813ptan20090203635.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... http://www.freshpatents.com/Inhibition-stat-1-dt20090813ptan20090203767.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to inhibitors of the transcription factor STAT-1, their use as therapeutic means as well as their use for the prevention or therapy of cardio-vascular complications like restenosis after percutaneous angioplasty or stenosis of venous bypasses, the graft versus host reaction, the ischemia/refusion-related damage in the context... http://www.freshpatents.com/Modulation-of-eif4e-bp2-expression-dt20090813ptan20090203765.php Tue, 18 Aug 2009 22:49:05 -0700 Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.... http://www.freshpatents.com/Vwf-aptamer-formulations-and-methods-for-use-dt20090813ptan20090203766.php Tue, 18 Aug 2009 22:49:05 -0700 The invention relates to the formulation, dosing, administration and use of an aptamer antagonist therapeutic that binds to von Willebrand Factor.... http://www.freshpatents.com/Modulation-of-the-integrin-linked-kinase-signaling-pathway-provides-beneficial-human-cardiac-hypertrophy-and-post-myocardial-infarction-remodeling-dt20090813ptan20090203769.php Tue, 18 Aug 2009 22:49:05 -0700 Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process for mediating a broadly adaptive form of human cardiac hypertrophy and a protective process for post myocardial infarction (MI), both comprising illiciting an... http://www.freshpatents.com/Nucleic-acid-containing-complex-dt20090813ptan20090203768.php Tue, 18 Aug 2009 22:49:05 -0700 A nucleic acid-containing complex, containing a nucleic acid and a biodegradable polymer, especially a positively-charged water-insoluble biodegradable polymer, is disclosed. The complex has excellent properties of sustainedly releasing a desired nucleic acid, especially DNA, to a site in need of a treatment. Since the complex can be taken up to... http://www.freshpatents.com/Prevention-and-treatment-of-cancer-and-other-diseases-dt20090813ptan20090203636.php Tue, 18 Aug 2009 22:49:05 -0700 Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a... http://www.freshpatents.com/Novel-cytostatic-7-deazapurine-nucleosides-dt20090813ptan20090203637.php Tue, 18 Aug 2009 22:49:05 -0700 wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds. The invention provides compounds of formula I:... http://www.freshpatents.com/Pharmaceutical-compositions-and-methods-for-metabolic-modulation-dt20090813ptan20090203638.php Tue, 18 Aug 2009 22:49:05 -0700 Pharmaceutical compositions include compounds with cytokinin activity to modulate glucose and/or lipid metabolism in a mammal. Especially preferred compounds include those comprising a purine scaffold, and it is further preferred that contemplated compositions are employed to prevent and/or treat various diseases, including pre-diabetes, insulin resistance, type-2 diabetes, Syndrome X, and... http://www.freshpatents.com/Crystalline-forms-of-gemcitabine-amide-prodrug-compositions-and-use-thereof-dt20090813ptan20090203640.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to novel crystal forms of an amide prodrug of gemcitabine, compositions thereof and methods for using.... http://www.freshpatents.com/Methylation-markers-for-diagnoses-and-treatment-of-cancers-dt20090813ptan20090203639.php Tue, 18 Aug 2009 22:49:05 -0700 Two hundred ten markers are provided which are epigenetically silenced in one or more cancer types. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can be useful therapeutically, for example, if the... http://www.freshpatents.com/Antibiotic-compositions-and-related-screening-methods-dt20090813ptan20090203641.php Tue, 18 Aug 2009 22:49:05 -0700 Moenomycin inhibits bacterial growth by clocking the transglycosylase activity of class A penicillin-binding proteins (PBPs), which are key enzymes in bacterial cell wall synthesis. The binding affinities of moenomycin A with various truncated PBPs were compared showing that the transmembrane domain is important for moenomycin binding. Full-length class-A PBPs from... http://www.freshpatents.com/Method-and-composition-for-avoiding-or-mitigating-the-formation-of-preservative-residues-on-the-surface-of-wood-treated-with-micronized-copper-containing-compositions-dt20090813ptan20090203643.php Tue, 18 Aug 2009 22:49:05 -0700 Disclosed is a wood preservative composition comprising micronized copper and copper-amine complex, wherein the copper component of the copper amine complex is from about 5% to about 50% by weight, based upon the total weight of copper in the composition. The copper amine complex serves to avoid wood surface “chalking”... http://www.freshpatents.com/Spray-dried-chitin-nanofibrils-method-for-production-and-uses-thereof-dt20090813ptan20090203642.php Tue, 18 Aug 2009 22:49:05 -0700 The invention relates to a novel method for production of nanofibrillar chitin, sustainable from an industrial manufacturing standpoint and suitable for producing chitin nanofibrils having improved properties and free from less crystalline components. The invention also relates to novel chitin nanofibrils obtained with said method and characterized by an increased... http://www.freshpatents.com/Broad-spectrum-disinfecting-and-sterilizing-composition-dt20090813ptan20090203645.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention relates to antimicrobial compositions including an aromatic dialdehyde and a quaternary ammonium compound wherein the aromatic dialdehyde is orthophthalaldehyde, isophthalaldehyde, terephthalaldehyde, or combinations thereof, and the ratio of aromatic dialdehyde to quaternary ammonium compound is from about 10:1 to about 1:5. The invention also relates to methods... http://www.freshpatents.com/Compositions-for-treating-and-or-preventing-diseases-characterized-by-the-presence-of-metal-ions-dt20090813ptan20090203644.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention generally relates to the treatment and/or prevention of Alzheimer's disease, other neurodegenerative diseases, and/or diseases characterized by the presence of certain metal ions, by using certain compositions including silicon-amino compounds. In some cases, a silicon-amino compound of the invention may be bidentate, tridentate, or otherwise polydentate, and... http://www.freshpatents.com/Use-of-sodium-narcistatin-for-reducing-internal-adhesions-and-fibrosis-dt20090813ptan20090203646.php Tue, 18 Aug 2009 22:49:05 -0700 The present invention concerns a method for reducing or preventing development of adhesions, fibrosis or scar tissue within serous body cavities by using sodium narcistatin.... http://www.freshpatents.com/5-fluoro-pyrimidine-derivatives-dt20090813ptan20090203647.php Tue, 18 Aug 2009 22:49:06 -0700 This present disclosure is related to the field of 5-fluoro pyrimidines and their derivatives and to the use of these compounds as fungicides.... http://www.freshpatents.com/Modified-phosphocalcic-compound-injectable-composition-containing-same-dt20090813ptan20090203648.php Tue, 18 Aug 2009 22:49:06 -0700 A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to... http://www.freshpatents.com/Dermatological-anti-wrinkle-agent-dt20090813ptan20090203649.php Tue, 18 Aug 2009 22:49:06 -0700 and/or a salt thereof, wherein R1, R2, and R3 represent a hydrogen atom or a methyl group. The anti-wrinkle cosmetic includes the anti-wrinkle agent. The dermatological anti-wrinkle agent comprises a tocopherol phosphate represented by the following formula (1): A dermatological anti-wrinkle agent and an anti-wrinkle cosmetic are stable and satisfactorily effective against... http://www.freshpatents.com/Use-of-phytate-as-agent-inhibiting-dissolution-of-crystals-of-calcium-salts-for-the-prevention-of-osteoporosis-dt20090813ptan20090203650.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to the use of myo-inositol hexaphosphate or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention or treatment of a disease associated with the dissolution of crystals of calcium salts, in particular osteoporosis. These compounds may be utilized in the manufacture... http://www.freshpatents.com/Use-of-sphingolipids-in-the-treatment-and-prevention-of-type-2-diabetes-mellitus-insulin-resistance-and-metabolic-syndrome-dt20090813ptan20090203651.php Tue, 18 Aug 2009 22:49:06 -0700 t is 0 or 1, or a precursor, a derivative or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the prevention and/or treatment of a disorder selected from the group consisting of insulin resistance, diabetes type 2 and Metabolic Syndrome. Q1 is a... http://www.freshpatents.com/Chiral-arylketones-in-the-treatment-of-neutrophil-dependent-inflammatory-diseases-dt20090813ptan20090203652.php Tue, 18 Aug 2009 22:49:06 -0700 where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia... http://www.freshpatents.com/Compositions-and-methods-using-apocynin-compounds-and-nitric-oxide-donors-dt20090813ptan20090203653.php Tue, 18 Aug 2009 22:49:06 -0700 The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The invention also provides novel kits comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and... http://www.freshpatents.com/Cosmetic-and-pharmaceutical-compositions-dt20090813ptan20090203654.php Tue, 18 Aug 2009 22:49:06 -0700 This invention also relates to the use of such a compound for both external and non-external applications. This invention relates to novel compounds that display retinoid like activities, including HB-EGF (Heparin Binding Epidermal Growth Factor) release from keratinocytes, cell proliferation, and epidermal thickening without the irritation potentials, such as release of... http://www.freshpatents.com/Prophylactic-docosahexaenoic-acid-therapy-for-patients-with-subclinical-inflammation-dt20090813ptan20090203655.php Tue, 18 Aug 2009 22:49:06 -0700 This invention is directed to methods and compositions which impede the development and progression of diseases associated with subclinical inflammation. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. The methods and compositions of the invention are also particularly suited to providing therapy for subclinical... http://www.freshpatents.com/Method-for-the-reduction-of-dangerous-blood-sugar-levels-dt20090813ptan20090203656.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to a method and procedure for reducing immediate serum glucose levels without resort to drugs. Specifically, the invention discloses a regular regimen comprising modest exercise, daily nutritional supplements and a series of specific, time sensitive steps, which, when followed will optimize the effects of the invention.... http://www.freshpatents.com/Dual-pharmacophores---pde4-muscarinic-antagonistics-dt20090813ptan20090203657.php Tue, 18 Aug 2009 22:49:06 -0700 pharmaceutical compositions and their use as dual chromaphores having inhibitory activity against PDE4 and muscarinic acetylcholine receptors (mAChRs), and thus being useful for treating respiratory diseases. The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof,... http://www.freshpatents.com/Method-of-enhancing-hair-growth-dt20090813ptan20090203659.php Tue, 18 Aug 2009 22:49:06 -0700 wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is... http://www.freshpatents.com/Neuroactive-steroid-compositions-and-methods-of-use-therefor-dt20090813ptan20090203658.php Tue, 18 Aug 2009 22:49:06 -0700 Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder... http://www.freshpatents.com/Therapeutic-ophthalmic-compositions-containing-retinal-friendly-excipients-and-related-methods-dt20090813ptan20090203660.php Tue, 18 Aug 2009 22:49:06 -0700 Pharmaceutical compositions suitable for administration into the interior of an eye of a person or animal are described. The present compositions include one or more components which are effective in providing a reduced toxicity relative to existing intraocular ophthalmic compositions. The present compositions include one or more therapeutic agents in... http://www.freshpatents.com/Betulinic-acid-derivatives-and-analogs-thereof-and-uses-therefor-dt20090813ptan20090203661.php Tue, 18 Aug 2009 22:49:06 -0700 Provided herein provided herein are novel analogs and derivatives of betulinic acid. Also provided is a method for inhibiting an activity of one or more specificity protein (Sp) transcription factors cells associated with a neoplastic disease using betulinic acid, betulinic acid analog(s) and/or derivative(s) effective to decrease expression of a... http://www.freshpatents.com/Novel-derivatives-of-cholest-4-en-3-one-oxime-pharmaceutical-compositions-containing-them-and-preparation-method-dt20090813ptan20090203662.php Tue, 18 Aug 2009 22:49:06 -0700 or one of its esters and/or of its addition salts with pharmaceutically acceptable acids, particularly as a cytoprotective drug, preferentially a cardioprotective and/or neuroprotective drug, the compounds of formula I wherein R is R2, R3, R4, R5 or R6 as novel compounds as well as their preparation method and use.... http://www.freshpatents.com/Chemical-compounds-dt20090813ptan20090203663.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to compounds that inhibit a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm blooded animals such as humans of diseases... http://www.freshpatents.com/-1s5s--3--56-dichloro-3-pyridinyl--36--diazabicyclo-3-2-0-heptane-dt20090813ptan20090203664.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.... http://www.freshpatents.com/Heterocyclic-substituted-phenyl-methanones-dt20090813ptan20090203665.php Tue, 18 Aug 2009 22:49:06 -0700 and to pharmaceutically acceptable acid addition salts thereof. are defined in the specification R2, and R1, wherein The present invention relates to compounds of formula I... http://www.freshpatents.com/Compounds-and-compositions-as-hedgehog-pathway-modulators-dt20090813ptan20090203666.php Tue, 18 Aug 2009 22:49:06 -0700 The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a... http://www.freshpatents.com/Pentadienamide-derivatives-dt20090813ptan20090203667.php Tue, 18 Aug 2009 22:49:06 -0700 or a pharmaceutically acceptable salt thereof, and the like. R5, R6, and R7 may be the same or different, and each represents a hydrogen atom or methyl) R4 represents substituted or unsubstituted aryl, a substituted or... http://www.freshpatents.com/Triazolopyridine-11-beta-hydroxysteroid-dehydrogenase-type-i-inhibitors-dt20090813ptan20090203668.php Tue, 18 Aug 2009 22:49:06 -0700 or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof wherein W, L, R3, R3a, R3b and R4 are defined herein. Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type... http://www.freshpatents.com/Combination-antidepressants-wafer-dt20090813ptan20090203670.php Tue, 18 Aug 2009 22:49:06 -0700 A sheet-like pharmaceutical preparation (dosage form) that quickly disintegrates on contact with moisture, based on hydrophilic polymers for the release of at least one active agent. The dosage form contains an active agent combination for treating depression, and at least one active agent selected from the antidepressant group of drugs.... http://www.freshpatents.com/Compositions-and-methods-for-the-treatment-of-addiction-and-other-neuropsychiatric-disorders-dt20090813ptan20090203669.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention is based, in part, on our discovery that certain types of therapeutic agents can be used in combination to treat a variety of neuropsychiatric and related disorders, including addiction (e.g., to a substance or to an activity) as well as to alleviate some of the symptoms experienced... http://www.freshpatents.com/Method-of-treating-cancer-dt20090813ptan20090203671.php Tue, 18 Aug 2009 22:49:06 -0700 Methods of treating cancer in patients comprising administering thereto aurora kinase inhibitors and TRAIL (tumor necrosis factor (TNF)-related apoptosis inducing ligand) inhibitors is disclosed.... http://www.freshpatents.com/Substituted-sulfonamide-compounds-dt20090813ptan20090203672.php Tue, 18 Aug 2009 22:49:06 -0700 wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these substituted sulfonamide compounds for the treatment and/or inhibition of pain or other conditions. Substituted sulfonamide compounds corresponding to the formula I′... http://www.freshpatents.com/4-heterocycloalkylpyri-mi-dines-process-for-the-preparation-thereof-and-their-use-as-medicaments-dt20090813ptan20090203673.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention encompasses compounds of general Formula (I) wherein X and R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.... http://www.freshpatents.com/Pyrimidine-compound-and-pests-controlling-composition-containing-the-same-dt20090813ptan20090203674.php Tue, 18 Aug 2009 22:49:06 -0700 wherein R1 represents a hydrogen atom, halogen atom or C1-C4 alkyl; R2 represents C3-C7 alkynyloxy; R3 represents a hydrogen atom, halogen atom or C1-C3 alkyl; X represents C4 polymethylene, in which a CH2—CH2 may be replaced with a CH═CH, optionally substituted with at least one substituent selected from the group... http://www.freshpatents.com/Sulfonyl-semicarbazides-semicarbazides-and-ureas-pharmaceutical-compositions-thereof-and-methods-for-treating-hemorrhagic-fever-viruses-including-infections-associated-with-arena-viruses-dt20090813ptan20090203675.php Tue, 18 Aug 2009 22:49:06 -0700 Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis... http://www.freshpatents.com/Dual-pharmacophores---pde4-muscarinic-antagonistics-dt20090813ptan20090203677.php Tue, 18 Aug 2009 22:49:06 -0700 and their use in the treatment of respiratory diseases, including anti-inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis. The present invention relates to novel compounds of Formula (I)... http://www.freshpatents.com/G-protein-coupled-receptor-agonists-dt20090813ptan20090203676.php Tue, 18 Aug 2009 22:49:06 -0700 Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.... http://www.freshpatents.com/Pharmaceutical-compositions-for-the-treatment-of-protozoan-parasitic-diseases-dt20090813ptan20090203678.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to the use of a Rho/ROCK/PI3K/Akt pathway modulator for the manufacture of a medicament intended for the prevention or the treatment of pathologies associated with an infection by a protozoan parasite.... http://www.freshpatents.com/Galenical-formulations-of-organic-compounds-dt20090813ptan20090203679.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to a solid oral dosage form comprising a therapeutically effective amount of aliskiren or a pharmaceutically acceptable salt thereof, a therapeutically effective amount of HCTZ and a hydrophilic filler selected from the group a carbohydrate or combinations thereof, e.g. sugars, sugar alcohols and starches or combinations... http://www.freshpatents.com/In-vivo-studies-of-crystalline-forms-of-meloxicam-dt20090813ptan20090203680.php Tue, 18 Aug 2009 22:49:06 -0700 The invention is directed to novel crystalline forms of meloxicam. These novel crystalline forms of meloxicam have improved bioavailability, an enhanced rate of dissolution and shorter time to Cmax in blood, as compared to pure meloxicam.... http://www.freshpatents.com/Novel-n--2-amino-phenyl--amide-derivatives-dt20090813ptan20090203681.php Tue, 18 Aug 2009 22:49:06 -0700 and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments containing such compounds. The compounds of the present invention show anti-proliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion. The invention also covers the use... http://www.freshpatents.com/Rapamycin-analogues-and-the-uses-thereof-in-the-treatment-of-neurological-disorders-dt20090813ptan20090203682.php Tue, 18 Aug 2009 22:49:06 -0700 Method of treatment of neurological disorders or complications due to stroke or head injury through the administration of a pharmaceutical composition including a pharmaceutically acceptable excipient or carrier and a compound of formula I are provided:... http://www.freshpatents.com/Bicyclic-heterocycles-pharmaceutical-compositions-containing-them-their-use-and-processes-for-preparing-them-dt20090813ptan20090203683.php Tue, 18 Aug 2009 22:49:06 -0700 wherein Ra, Rb, Rc, A, B, C, D, and X are as defined herein, or a tautomer, stereoisomer, or salt thereof, particularly a physiologically acceptable salt thereof. In addition, pharmaceutical compositions comprising an effective amount of a compound of formula (I), methods for the treatment or prophylaxis of benign or... http://www.freshpatents.com/Tyrosine-kinase-inhibitors-dt20090813ptan20090203684.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine derivatives of formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat... http://www.freshpatents.com/Aminoalkyl-amidomethyl-substituted-2--4-sulphonylamino---3-hydroxy-34-dihydro-2h-chroman-6-yl-derivatives-dt20090813ptan20090203686.php Tue, 18 Aug 2009 22:49:06 -0700 wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n have the meanings given in the description, and also a process for the preparation of these compounds and intermediate products of this process. Furthermore, pharmaceutical compositions comprising the compounds of Formula I and related methods of treatment. Compounds... http://www.freshpatents.com/Anti-proliferative-compounds-from-a-3-aryl-coumarine-or-3-aryl-quinolin-2-one-and-uses-thereof-dt20090813ptan20090203685.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention is directed to molecules deriving from a 3-aryl-coumarine or 3-aryl-quinolin-2-one and having potent anti-proliferative and/or cytotoxic activity, especially against tumoral cells. The present invention also concerns the uses of these molecules in therapeutic application, for the treatment of different cancers. The invention also discloses the use of... http://www.freshpatents.com/Abca-1-elevating-compounds-and-methods-dt20090813ptan20090203689.php Tue, 18 Aug 2009 22:49:06 -0700 useful for treating various disease states, in particular, insulin resistance, diabetes, dyslipidemia, coronary artery disease, and inflammation. The compounds of the present invention elevate cellular expression of the ABCA-1 gene as well as increasing the level of ABCA-1 protein, which may result in an increase in HDL levels in the... http://www.freshpatents.com/Fused-ring-heterocycle-kinase-modulators-dt20090813ptan20090203687.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.... http://www.freshpatents.com/Heterocyclic-compounds-dt20090813ptan20090203688.php Tue, 18 Aug 2009 22:49:06 -0700 wherein the substituents are as defined in the specification, processes for the preparation thereof; to pharmaceuticals containing such compounds, in particular for the use in one or more Protein tyrosine kinase mediated diseases. The invention relates to compounds of formula I and salts thereof... http://www.freshpatents.com/5-substituted-indazoles-as-kinase-inhibitors-dt20090813ptan20090203690.php Tue, 18 Aug 2009 22:49:06 -0700 wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4,... http://www.freshpatents.com/Novel-1h-indazole-compounds-dt20090813ptan20090203691.php Tue, 18 Aug 2009 22:49:06 -0700 Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or... http://www.freshpatents.com/Novel-chemical-compounds-dt20090813ptan20090203692.php Tue, 18 Aug 2009 22:49:06 -0700 This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.... http://www.freshpatents.com/Therapeutic-agent-for-liver-fibrosis-dt20090813ptan20090203693.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention provides a therapeutic agent for hepatic fibrosis and a method for treatment of hepatic fibrosis. 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide or an analogue thereof can prevent the fibrillation in the liver, and therefore can be used as a therapeutic agent for hepatic fibrosis or in the method for treatment of hepatic... http://www.freshpatents.com/Inhibitors-of-undecaprenyl-pyrophosphate-synthase-dt20090813ptan20090203694.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these compounds for treating bacterial disease, such as bacterial infection.... http://www.freshpatents.com/Aryl--and-heteroaryl-ethyl-acylguanidine-derivatives-their-preparation-and-their-application-in-therapeutics-dt20090813ptan20090203696.php Tue, 18 Aug 2009 22:49:06 -0700 wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the... http://www.freshpatents.com/Compounds-iv-dt20090813ptan20090203695.php Tue, 18 Aug 2009 22:49:06 -0700 to pharmaceutical compositions comprising the compounds, to processes for their preparation, and to the use of the compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias. The present application relates to new compounds of formula (I),... http://www.freshpatents.com/Heterocyclic-type-cinnamide-derivative-dt20090813ptan20090203697.php Tue, 18 Aug 2009 22:49:06 -0700 (In the formula, Ar1 represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like; Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group or the like; X1 represents —CR3═CR4— (wherein R3 and R4... http://www.freshpatents.com/Compounds-for-enzyme-inhibition-dt20090813ptan20090203698.php Tue, 18 Aug 2009 22:49:06 -0700 Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of... http://www.freshpatents.com/Aminomethylpyridine-derivatives-method-for-preparing-same-and-therapeutic-use-thereof-dt20090813ptan20090203699.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention pertains to aminomethylpyridine derivatives, to their preparation and to their therapeutic application.... http://www.freshpatents.com/Azolylmethyloxiranes-their-use-for-controlling-phytopathogenic-fungi-and-compositions-comprising-them-dt20090813ptan20090203700.php Tue, 18 Aug 2009 22:49:06 -0700 and to the plant-compatible acid addition salts or metal salts thereof, to the use of the compounds of the formula I for controlling phytopathogenic fungi and to compositions comprising these compounds. A or B is phenyl which is optionally substituted by one to three of the following... http://www.freshpatents.com/Prophylactic-and-or-therapeutic-agent-for-rheumatoid-arthritis-dt20090813ptan20090203701.php Tue, 18 Aug 2009 22:49:06 -0700 A prophylactic and/or therapeutic agent for rheumatoid arthritis, comprising 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one and an HMG-CoA reductase inhibitor in combination. A medicament having excellent therapeutic and prophylactic effects on rheumatoid arthritis is provided.... http://www.freshpatents.com/Inhibitors-of-p38-dt20090813ptan20090203702.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions... http://www.freshpatents.com/Quinoxaline-derivative-and-light-emitting-element-light-emitting-device-and-electronic-device-using-quinoxaline-derivative-dt20090813ptan20090203704.php Tue, 18 Aug 2009 22:49:06 -0700 An object is to provide a novel quinoxaline derivative. Another object is to provide a light-emitting element with low driving voltage. Still another object is to provide a light-emitting element with low power consumption. Yet another object is to provide a light-emitting device and an electronic device each having low... http://www.freshpatents.com/Thienopyrimidine-derivatives-dt20090813ptan20090203703.php Tue, 18 Aug 2009 22:49:06 -0700 or salts thereof, which exhibit an inhibitory effect on PDE9, and are therefore useful for prevention or treatment of overactive bladder syndrome, pollakiuria, urinary incontinence, dysuria associated with prostatic hyperplasia, urolithiasis, Alzheimer's disease, chronic obstructive pulmonary disease, myocardial infarction, thrombosis, diabetes and the like.... http://www.freshpatents.com/Spiro-compounds-as-npy-y5-receptor-antagonists-dt20090813ptan20090203705.php Tue, 18 Aug 2009 22:49:06 -0700 processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder. R4 is C3-C8 cycloalkyl;... http://www.freshpatents.com/Lysine-based-polymeric-linkers-dt20090813ptan20090203706.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention provides polymeric linkers containing branching moieties. Methods of making the polymeric linkers and methods of making conjugates using the same are also disclosed.... http://www.freshpatents.com/Methods-for-treating-pain-dt20090813ptan20090203707.php Tue, 18 Aug 2009 22:49:06 -0700 This invention relates to methods for treating a patient suffering from neuropathic or nociceptive pain which may be mechanical, visceral, and/or inflammatory in nature, comprising administering a therapeutically effective amount of Ranolazine to a patient in need thereof.... http://www.freshpatents.com/Novel-substituted-1-h-quinazoline-24-dione-derivatives-preparation-method-thereof-and-pharmaceutical-composition-containing-the-same-dt20090813ptan20090203708.php Tue, 18 Aug 2009 22:49:06 -0700 Disclosed herein are novel substituted-1H-quinazoline-2,4-dione derivatives, a preparation method thereof, and a pharmaceutical composition containing the same. The novel substituted-1H-quinazoline-2,4-dione derivatives are excellent in binding affinity and selectivity for 5-HT6 receptors over other receptors, inhibit serotonin(5-HT)-stimulated cAMP accumulation, and disrupt apomorphine(2 mg/kg, i.p.)-induced hyperactivity in rats. Thanks to these effects,... http://www.freshpatents.com/Pharmaceutical-dosage-form-for-oral-administration-of-tyrosine-kinase-inhibitor-dt20090813ptan20090203709.php Tue, 18 Aug 2009 22:49:06 -0700 A pharmaceutical dosage form comprises a solid dispersion product of at least one tyrosine kinase inhibitor, at least one pharmaceutically acceptable polymer, and at least one pharmaceutically acceptable solubilizer.... http://www.freshpatents.com/Novel-piperidine-derivative-dt20090813ptan20090203710.php Tue, 18 Aug 2009 22:49:06 -0700 Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty liver, circulatory system diseases, for example, stenocardia, acute/congestive cardiac insufficiency, cardiac infarction, coronary arteriosclerosis, hypertension, nephropathy, sleep disorder and various diseases accompanied by sleep... http://www.freshpatents.com/Inhibitors-of-p38-map-kinase-dt20090813ptan20090203711.php Tue, 18 Aug 2009 22:49:06 -0700 wherein R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7cycloalkyl, aryl or heteroaryl or —(C═O)R3, —(C═O)OR3, or —(C═O)NR3 wherein R3 is hydrogen or optionally... http://www.freshpatents.com/Urea-derivative-dt20090813ptan20090203712.php Tue, 18 Aug 2009 22:49:06 -0700 p is 0 to 6. n is 0 or 1, R2 and R3 are each independently hydrogen or the like, R1 is hydrogen or the like, Z is —NR7— or the like, Y is a group of the formula: X is hydrogen or the like, wherein its pharmaceutically acceptable salt or solvate thereof, A compound represented by the formula: Disclosed... http://www.freshpatents.com/Hedgehog-pathway-antagonists-to-treat-disease-dt20090813ptan20090203713.php Tue, 18 Aug 2009 22:49:06 -0700 Compounds, compositions, kits and methods for modulating hedgehog pathway activity, and treating conditions related to abnormal or aberrant hedgehog pathway activity, are disclosed.... http://www.freshpatents.com/Furo-32-b-pyrrol-3-one-derivatives-and-their-use-as-cysteinyl-proteinase-inhibitors-dt20090813ptan20090203714.php Tue, 18 Aug 2009 22:49:06 -0700 The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease, diseases involving matrix or cartilage degradation, and bone cancer disorders such as... http://www.freshpatents.com/Novel-2-hetarylthiazole-4-carboxamide-derivatives-their-preparation-and-use-as-pharmaceuticals-dt20090813ptan20090203715.php Tue, 18 Aug 2009 22:49:06 -0700 The present invention relates to 2-hetarylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof... http://www.freshpatents.com/Pyrimidine-low-molecular-weight-ligands-for-modulating-hormone-receptors-dt20090813ptan20090203716.php Tue, 18 Aug 2009 22:49:06 -0700 R7 and R8 independently are selected from H, lower alkyl, aralkyl and cycloalkyl. R6 is selected from H, lower alkyl and aralkyl; R5 is selected from lower alkyl, aralkyl, cycloalkyl and haloalkyl;... http://www.freshpatents.com/Fused-heterocyclic-compound-dt20090813ptan20090203717.php Tue, 18 Aug 2009 22:49:07 -0700 wherein W is C(R1) or N, each A is an optionally substituted aryl group or a heteroaryl group, X1 is —NR3—Y1—, —O—, —S—, —SO—, —SO2— or —CHR3— wherein R3 is a hydrogen atom or an optionally substituted aliphatic hydrocarbon group, or R3 is optionally bonded to A to form an... http://www.freshpatents.com/Cancer-treatment-method-dt20090813ptan20090203718.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to a method of treating cancer in a mammal and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering an erb family inhibitor and an IGF-1R inhibitor to a mammal suffering from a cancer.... http://www.freshpatents.com/Enhancing-treatment-of-mdr-cancer-with-adenosine-a3-antagonists-dt20090813ptan20090203719.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention discloses the use of high affinity adenosine A3 receptor antagonists for enhancing chemotherapeutic treatment of cancers expressing adenosine A3 receptors and cancers expressing P-glycoprotein or MRP. In preferred embodiments, adenosine A3 receptor antagonists are administered before or during administration of a taxane family, vinca alkaloid, camptothecin or... http://www.freshpatents.com/Methods-for-inhibiting-cell-growth-dt20090813ptan20090203720.php Tue, 18 Aug 2009 22:49:07 -0700 Cell growth is inhibited and/or cell death is induced in a cell by administering an RXR agonist and an inhibitor of casein kinase 1α. A cell or a tissue can be screened for enhanced susceptibility to cell death or interference with cell growth. Conditions characterized by uncontrolled cell growth or... http://www.freshpatents.com/Use-of-siramesine-in-the-treatment-of-cancer-dt20090813ptan20090203721.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to the treatment of cancer. In particular, the invention provides pharmaceutical compositions comprising siramesine for the treatment of cancer. The invention further provides a method of treatment comprising administering siramesine to a patient suffering from cancer.... http://www.freshpatents.com/67-unsaturated-7-carbamoyl-substituted-morphinan-derivative-dt20090813ptan20090203723.php Tue, 18 Aug 2009 22:49:07 -0700 or a pharmaceutically acceptably salt, or a solvate thereof is provided. wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., R3 is hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally... http://www.freshpatents.com/Novel-compositions-and-methods-for-enhancing-potency-or-reducing-adverse-side-effects-of-opiold-agonists-dt20090813ptan20090203722.php Tue, 18 Aug 2009 22:49:07 -0700 The invention generally relates to novel compositions and methods with an opioid agonist and an opioid antagonist to differentially dose a human subject so as to either enhance analgesic potency without attenuating an adverse side effect of the agonist, or alternatively maintain the analgesic potency of the agonist while attenuating... http://www.freshpatents.com/Solid-and-crystalline-dutasteride-and-processes-for-preparation-thereof-dt20090813ptan20090203724.php Tue, 18 Aug 2009 22:49:07 -0700 The solid state chemistry of 17β-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-α-androst-1-en-3-one of which the international nonproprietary name is Dutasteride (the active ingredient in products marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) and its process for preparing. The synthetic process comprises formation of the mixed anhydride, its subsequent reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence... http://www.freshpatents.com/Androgen-receptor-modulator-compounds-and-methods-dt20090813ptan20090203725.php Tue, 18 Aug 2009 22:49:07 -0700 Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors; and to methods for making and using such compounds. Also provided are compositions containing such compounds and methods for making and using such compositions.... http://www.freshpatents.com/Novel-pharmaceutical-composition-and-its-use-in-a-method-for-treatment-of-patients-with-upper-respiratory-mucosal-congestion-dt20090813ptan20090203727.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to a pharmaceutical composition including loratadine or a pharmaceutically acceptable form thereof, and phenylephrine or a pharmaceutically acceptable form thereof, for treating upper respiratory/mucosal congestion, optionally by administering to a patient four times a day.... http://www.freshpatents.com/Substituted-tetrahydroquinolines-as-antibacterial-agents-dt20090813ptan20090203726.php Tue, 18 Aug 2009 22:49:07 -0700 The variables in structural formula (I-a) are described herein. A method of treating a subject for a bacterial infection includes administering to a subject in need of treatment for a bacterial infection an effective amount of a compound represented by structural formula (I-a), or a pharmaceutically acceptable salt, solvate, or hydrate... http://www.freshpatents.com/Naphthalamide-derivatives-having-antiproliferative-activity-dt20090813ptan20090203728.php Tue, 18 Aug 2009 22:49:07 -0700 The invention relates to compounds for use in medicine. The compounds are of general formula (I) as disclosed herein and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers thereof, wherein X, X′ and X″ are independently O or S; Z is N or P; R3 is optional and... http://www.freshpatents.com/Bicyclic-ppat-inhibitors-as-antibacterial-agents-dt20090813ptan20090203730.php Tue, 18 Aug 2009 22:49:07 -0700 Disclosed are compounds of Formula I, pharmaceutical compositions comprising Formula I and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia... http://www.freshpatents.com/Process-for-producing-high-purity-prasugrel-and-acid-addition-salt-thereof-dt20090813ptan20090203729.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for... http://www.freshpatents.com/Treatment-of-depression-and-other-affective-disorders-dt20090813ptan20090203731.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to use of gaboxadol for preparing a pharmaceutical composition for treating depression. Moreover, it relates to the use of gaboxadol for the preparation of a pharmaceutical composition to be used in combination with a serotonin reuptake inhibitor, or any other compound which causes an elevation in... http://www.freshpatents.com/Thiazolones-for-use-as-p13-kinase-inhibitors-dt20090813ptan20090203732.php Tue, 18 Aug 2009 22:49:07 -0700 Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection,... http://www.freshpatents.com/Pharmaceutical-composition-dt20090813ptan20090203733.php Tue, 18 Aug 2009 22:49:07 -0700 This invention relates to a pharmaceutical composition for mammals and, more particularly, to a pharmaceutical composition which enhances the action of an anaesthetic used in both human and veterinary applications, which, at least partly, reduces the risk of respiratory depression and enhances pulmonary perfusion. The pharmaceutical composition is characterised in... http://www.freshpatents.com/F1f0-atpase-inhibitors-and-related-methods-dt20090813ptan20090203734.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to inhibitors of mitochondrial F1F0-ATPase, methods for their discovery, and their therapeutic use. In particular, the present invention provides the compound PK11195 and structurally and functionally related compounds as F1F0-ATPase inhibitors, and methods of using such inhibitors as therapeutic agents to treat a number of conditions.... http://www.freshpatents.com/Treatments-for-neuropathy-dt20090813ptan20090203735.php Tue, 18 Aug 2009 22:49:07 -0700 Small fiber neuropathy is treated or prevented by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat or prevent neuropathy in the subject. Glial cell-derived neurotrophic factor (GDNF) receptors are modulated with the subject active quinoline compounds,... http://www.freshpatents.com/Piperidine-sulphonamide-derivatives-dt20090813ptan20090203736.php Tue, 18 Aug 2009 22:49:07 -0700 wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds can be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag... http://www.freshpatents.com/Pyrrole-derivatives-as-positive-allosteric-modulators-of-metabotropic-receptors-dt20090813ptan20090203737.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to new compounds which are Pyrrole derivatives of formula (I) wherein A, B, P, Q5W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by... http://www.freshpatents.com/Pharmaceutical-composition-for-treating-bulimia-and-depression-arising-from-bulimia-dt20090813ptan20090203738.php Tue, 18 Aug 2009 22:49:07 -0700 Provided is a pharmaceutical composition for the treatment of bulimia in which a cholinesterase inhibitor is combined with at least one member selected from the group consisting of sibutramine, a pharmacologically acceptable salt thereof, an active metabolite thereof, a prodrug thereof and a solvate thereof. The pharmaceutical composition is useful... http://www.freshpatents.com/Anti-inflammatory-agents-dt20090813ptan20090203739.php Tue, 18 Aug 2009 22:49:07 -0700 The invention provides compounds, pharmaceutical compositions and uses of compounds of general formula (I) or a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended to treat an inflammatory disorder; wherein z X is 1, 2 or 4; X is —CO—Yk—(R1)n or SO2—Yk—(R1)n; k is 0 or 1;... http://www.freshpatents.com/2-phenylpropionic-acid-derivatives-and-pharmaceutical-compositions-containing-them-dt20090813ptan20090203740.php Tue, 18 Aug 2009 22:49:07 -0700 4-(trifluoromethanesulfonyloxyphenyl)propionic acid derivatives and pharmaceutical composition containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, these... http://www.freshpatents.com/Broadspectrum-2-amino-benzothiazole-sulfonamide-hiv-protease-inhibitors-dt20090813ptan20090203742.php Tue, 18 Aug 2009 22:49:07 -0700 wherein R1 is hexahydrofuro[2,3-b]furanyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, or phenyl optionally substituted with one or more substituents independently selected from C1-6alkyl, hydroxy, amino, halogen, aminoC1-4alkyl and mono- or di(C1-4alkyl)amino; R2 is hydrogen or C1-6alkyl; L is a direct bond, —O—, C1-6alkanediyl-O— or —O—C1-6alkanediyl; R3 is phenylC1-4alkyl; R4 is C1-6alkyl; R5... http://www.freshpatents.com/Crystals-of-benzoxadiazole-derivative-dt20090813ptan20090203741.php Tue, 18 Aug 2009 22:49:07 -0700 Means for Resolution A solving means includes β-form crystal of 4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole, which shows an endothermic peak at 145 to 150° C. according to a differential scanning calorimeter analysis (DSC analysis) and shows X-ray powder diffraction peaks at 9.8, 11.1, 12.8, 13.3, 17.1, 20.2, 21.2 and 22.3 in 2θ(°), and the... http://www.freshpatents.com/Small-molecule-entry-inhibitors-dt20090813ptan20090203743.php Tue, 18 Aug 2009 22:49:07 -0700 N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9—; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is —C(═O)—, —O—C(═O)—,... http://www.freshpatents.com/Novel-pyridine-derivatives-dt20090813ptan20090203744.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to novel pyridine derivatives of the formula (I), their stereoisomers, and their pharmaceutically acceptable salts, and compositions. The present invention more particularly provides novel pyridine derivatives of the general formula (I).... http://www.freshpatents.com/Heterocyclic-compounds-for-the-inhibition-of-integrins-and-use-thereof-dt20090813ptan20090203745.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to compounds of formula (I) wherein: A is a radical selected from the group comprising aromatic heterocyclic 5-membered ring systems; Ar is a radical selected from the group comprising optionally substituted 5- and 6-membered aromatic ring systems, whereby the ring system contains 0, 1, 2 or... http://www.freshpatents.com/Synergistic-insecticidal-composition-containing-chloronicotynyle-and-pyrethroids-compounds-dt20090813ptan20090203746.php Tue, 18 Aug 2009 22:49:07 -0700 A synergistic insecticidal composition is formed containing a Chloronicotynyle compound and a Pyrethroids compound. The Chloronicotynyle compound is provided in an amount preferably ranging from 0.1 to 5.0% by weight of the synergistic insecticidal composition. The Pyrethroids compound is provided in an amount preferably ranging from 1 to 60% by... http://www.freshpatents.com/Novel-chemical-compounds-and-the-uses-thereof-as-a-medicine-dt20090813ptan20090203747.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases. Given that certain members of said family are novel compounds which have never been described, the invention... http://www.freshpatents.com/Nicotinic-acid-compositions-for-treating-hyperlipidemia-and-related-methods-therefor-dt20090813ptan20090203748.php Tue, 18 Aug 2009 22:49:07 -0700 An orally administered antihyperlipidemia composition according to the present invention includes from about 250 to about 3000 parts by weight of nicotinic acid, and from about 5 to about 50 parts by weight of hydroxypropyl methylcellulose. Also, a method of treating hyperlipidemia in a hyperlipidemic having a substantially periodic physiological... http://www.freshpatents.com/5-ht2c-receptor-agonists-as-anorectic-agents-dt20090813ptan20090203750.php Tue, 18 Aug 2009 22:49:07 -0700 This invention relates to compounds which modulate receptors of the 5-HT2 family of receptors, and particularly to compounds which modulate 5-HT2C receptors. Compounds of the invention include agonists and selective agonists for the 5-HT2C receptor Compounds of the invention include selective agonists for the 5-HT2C receptor which exhibit significantly less... http://www.freshpatents.com/Agent-for-control-of-degranulation-reaction-and-cytokine-production-dt20090813ptan20090203749.php Tue, 18 Aug 2009 22:49:07 -0700 To provide an agent capable of controlling the degranulation reaction and/or cytokine production of mast cell and the like. The present invention provides an agent for controlling a degranulation reaction and an agent for controlling a cytokine production, comprising a substance capable of controlling an intracellular zinc ion concentration, particularly,... http://www.freshpatents.com/Novel-124-thiadiazolium-derivatives-as-melanocortin-receptor-modulators-dt20090813ptan20090203751.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II... http://www.freshpatents.com/Compounds-for-nonsense-suppression-and-methods-for-their-use-dt20090813ptan20090203752.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a... http://www.freshpatents.com/7--2-amino-1-hydroxy-ethyl--4-hydroxybenzothiazol-2-3h--one-derivatives-as-beta2-adrenoreceptor-agonists-dt20090813ptan20090203753.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4′, R5′, R6, R7, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.... http://www.freshpatents.com/Anti-bacterial-drug-targeting-of-genome-maintenance-interfaces-dt20090813ptan20090203754.php Tue, 18 Aug 2009 22:49:07 -0700 Methods for the design and identification of novel antimicrobial compounds are provided, as well as antimicrobial compounds identified using these methods. Pharmaceutical compositions that include these antimicrobial compounds are provided as well. The antimicrobial compounds inhibit the binding of a prokaryotic single-stranded DNA binding protein to a polypeptide. In some... http://www.freshpatents.com/Use-of-crf1-receptor-antagonists-for-preparing-a-drug-for-treating-metabolic-syndrome-and-or-obesity-and-or-dyslipoproteinemia-dt20090813ptan20090203755.php Tue, 18 Aug 2009 22:49:07 -0700 for the manufacture of a medicament for the prevention and/or the treatment of metabolic syndrome and/or obesity and/or dyslipoproteinemia. or one of its pharmaceutically acceptable salts, An object of the present invention is the use of a compound of formula (I):... http://www.freshpatents.com/Biocidal-compositions-dt20090813ptan20090203756.php Tue, 18 Aug 2009 22:49:07 -0700 x is a number from 3 to 10. R is a linear or branched butyl group and in which R—(O—CH2—CH2)x—O—H  (I) b) at least one solvent according to the formula I a) at least one biocidal active substance The present invention relates to biocidal compositions... http://www.freshpatents.com/Ethylene-glycol-esters-as-photoactive-agents-dt20090813ptan20090203757.php Tue, 18 Aug 2009 22:49:07 -0700 R2 is vinyl or a derivative form thereof. each n is independently an integer of 0-6; and wherein each R1 is independently alkyl (1-6C);... http://www.freshpatents.com/Alpha-crystalline-form-of-the-arginine-salt-of-perindopril-a-process-for--its-preparation-and-pharmceutical-compositions-containing-it--dt20090813ptan20090203758.php Tue, 18 Aug 2009 22:49:07 -0700 Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme. characterised by its powder X-ray diffraction diagram. α-crystalline form of the compound of formula (I):... http://www.freshpatents.com/Cyclic-agonists-and-antagonists-of-c5a-receptors-and-g-protein-coupled-receptors-dt20090813ptan20090203760.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to novel cyclic or constrained acyclic compounds which modulate the activity of G protein-coupled receptors and are useful in the treatment of conditions mediated by G protein-coupled receptors, for example, inflammatory conditions.... http://www.freshpatents.com/Pharmaceutical-formulation-of-nitrooxyderivatives-of-nsaids-dt20090813ptan20090203759.php Tue, 18 Aug 2009 22:49:07 -0700 d) optionally an oil or semi-solid fat and/or a short-chain alcohol. wherein m=0-10; and H2N—(CH2)m—(C6H4)—COOH  (II) c) a carbonyl scavenger compound selected from free acid forms, salts, carboxylic acid esters derivatives of a compound of formula (II) b) one or more surfactants; a) one... http://www.freshpatents.com/Process-for-preparing--3-oxo-23-dihydro-1h-isoindol-1-yl--acetylguanidine-derivatives-dt20090813ptan20090203761.php Tue, 18 Aug 2009 22:49:07 -0700 via 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives or 3-(2-carbamoylphenyl)-acrylic ester derivatives as intermediates, to a process for optical resolution, and to intermediates of the process according to the invention. The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I... http://www.freshpatents.com/Methods-for-the-production-of-biliverdin-dt20090813ptan20090203762.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to compositions and methods for the production of biliverdin. In particular, the invention concerns methods for producing biliverdin in yeast, especially Candida albicans, and other microorganisms.... http://www.freshpatents.com/Substituted-benzhydrylethers-dt20090813ptan20090203763.php Tue, 18 Aug 2009 22:49:07 -0700 Disclosed herein are substituted benzhydrylethers of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of their use thereof.... http://www.freshpatents.com/Inhibitors-of-semicarbazide-sensitive-amine-oxidase--ssao--and-vap-1-mediated-adhesion-useful-for-treatment-and-prevention-of-diseases-dt20090813ptan20090203764.php Tue, 18 Aug 2009 22:49:07 -0700 Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several... http://www.freshpatents.com/Compositions-and-methods-for-modulating-apoptosis-in-cells-over-expressing-bcl-2-family-member-proteins-dt20090813ptan20090203770.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention provides agents and compositions for modulating the apoptotic state of a cell. The agents comprise derivatives of antimycins which bind to an anti-apoptotic Bcl-2 family member protein. Further, the agents preferentially induce apoptosis in cells that over-express anti-apoptotic Bcl-2 family member proteins and typically exhibit reduced binding... http://www.freshpatents.com/Novel-intermediate-for-halichondrin-b-analog-synthesis-and-novel-desulfonylation-reaction-used-for-the-intermediate-dt20090813ptan20090203771.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention provides a novel method for producing a compound represented by formula (III) shown below, which comprises treating a compound represented by formula (I) shown below with a trivalent chromium compound and at least one kind of metal selected from the group consisting of manganese and zinc in... http://www.freshpatents.com/Vaginal-health-products-dt20090813ptan20090203772.php Tue, 18 Aug 2009 22:49:07 -0700 The invention provides compositions and methods for increasing cell growth, stimulating cell turnover and promoting the secretion of mucus within the reproductive tract of a female mammal.... http://www.freshpatents.com/Compounds-for-the-treatment-of-non-autoimmune-type-2-diabetes-mellitus-and-or-syndrome-x-dt20090813ptan20090203773.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to compounds of the formula (I); wherein R1 is H, CH3 or OCH3; R3=H, OH, CH3, OCH3, O-glucose or benzoyloxy; R4=H; R5=H or OH; R6=H or OCH3; R7=H, CH3, OCH3, cinnamoyloxy or (3,4,5-trimethoxy)-benzoyloxy; R8=H, OH, CH3 or OCH3; or R7 and R8 form together a group... http://www.freshpatents.com/Substituted-benzyl-ester-derivative-and-use-thereof-dt20090813ptan20090203774.php Tue, 18 Aug 2009 22:49:07 -0700 According to the present invention, a stable capsinoid derivative is provided, and a pharmaceutical composition, a food composition, a cosmetic composition and the like containing the derivative as an active ingredient can be provided. (2) when R1 is a hydroxyl group, then R2 is not a hydroxyl group and an acetoxy... http://www.freshpatents.com/Novel-compound-and-a-novel-microorganism-for-producing-the-novel-compound-dt20090813ptan20090203775.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to a novel compound represented as by formula (I). The present invention also provides a novel strain named as Alternaria alternata var. monosporus, which can produce the compound of formula (I). The inventive strain is cultured in the medium to produce and mass the inventive compound... http://www.freshpatents.com/Methods-of-using-menthol-propyleneglycol-carbonate-and-analogs-thereof-for-producing-anti-inflammatory-and-anti-angiogenic-effects-dt20090813ptan20090203776.php Tue, 18 Aug 2009 22:49:07 -0700 Menthol propyleneglycal-carbonate, analogs thereof and compositions containing such compounds are administered to mammals, preferably humans, to produce anti-inflammatory or anti-angiogenic effects.... http://www.freshpatents.com/Organic-compounds-dt20090813ptan20090203777.php Tue, 18 Aug 2009 22:49:07 -0700 The invention describes novel pharmaceutically acceptable salt forms of camostat, processes for lyophilisation, taste-masked formulations, nebulised formulations and the use of each of the fore-going in the treatment of respiratory diseases, particularly cystic fibrosis and chronic obstructive pulmonary disease (COPD).... http://www.freshpatents.com/Esters-of-long-chain-alcohols-and-preparation-thereof-dt20090813ptan20090203779.php Tue, 18 Aug 2009 22:49:07 -0700 Disclosed is a composition and methods of treating a skin condition. The ester includes an ester and a dermatologically acceptable carrier. The ester is represented by the general formula 1:... http://www.freshpatents.com/Fatty-acid-analogues-i-e--including-dha-derivatives-for-uses-as-a-medicament-dt20090813ptan20090203778.php Tue, 18 Aug 2009 22:49:07 -0700 A compound of formula (I) wherein R1 and R2 are different and each is chosen from a methyl group and a hydrogen atom; wherein X is chosen from a carboxylic acid group, a carboxylate group, a carboxamide group; or any pharmaceutically acceptable salt, solvate, complex, or pro-drug of said compound.... http://www.freshpatents.com/Use-of-a-polyunsaturated-fatty-acid-compound-dt20090813ptan20090203780.php Tue, 18 Aug 2009 22:49:07 -0700 A polyunsaturated fatty acid having 20 carbon atoms and four double bonds, or a derivative thereof, in an orally administrable form, can be used to treat or prevent obesity and/or for weight management. The polyunsaturated fatty acid may, for example, be used in the form of a food supplement, a... http://www.freshpatents.com/N-n-acyloxypropyl-lysine-methyl-ester-and-nn-bis-n-acyloxypropyl--lysine-methyl-ester-type-compounds-and-use-thereof-as-surface-active-agents-with-an-antimicrobial-activity-dt20090813ptan20090203781.php Tue, 18 Aug 2009 22:49:07 -0700 The invention relates to novel compounds having an amphiphilic character (cationic, anionic, amphoteric and non-ionic), derivatives of n acyloxypropyl-type lysine amino acid according to general formula (I), which are intended to be used in the food, pharmaceutical and cosmetic industries as surface-active agents having a self-aggregating capacity and antimicrobial properties.... http://www.freshpatents.com/Alpha-2-delta-ligands-for-fibromyalgia-and-other-disorders-dt20090813ptan20090203782.php Tue, 18 Aug 2009 22:49:07 -0700 R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The... http://www.freshpatents.com/Therapeutic-agent-for-acute-cerebral-infarct-dt20090813ptan20090203783.php Tue, 18 Aug 2009 22:49:07 -0700 An agent for treating acute cerebral infarction, comprising (2R)-2-propyloctanoic acid or a salt thereof, which is used for administration after a lapse of time of from about 5 hours to about 72 hours from the onset of the disease is useful for treating acute cerebral infarction, since it safely improves... http://www.freshpatents.com/Method-and-process-for-producing-youthful-appearing-small-pored-and-smooth-skin-dt20090813ptan20090203785.php Tue, 18 Aug 2009 22:49:07 -0700 A method and process for producing youthful appearing, small-pored, and smooth skin by pre-treating the skin topically with retinoic acid, applying carbon particles on the skin, removing the carbon particles by exploding them with laser light, and post-treating the skin topically with retinoic acid. When treating the face, removing the... http://www.freshpatents.com/Treatment-regimen-for-n-myc-c-myc-and-l-myc-amplified-and-overexpressed-tumors-dt20090813ptan20090203784.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to methods and compositions for treating diseases. More specifically, the present invention relates to the administration of multiple drugs as part of a treatment of disease. Specific embodiments of the invention relate to a treatment regimen for neuroblastomas and other N-MYC, c-MYC, and L-MYC amplified and... http://www.freshpatents.com/Method-of-enhancing-reproductive-function-of-mammals-by-feeding-of-conjugated-linoleic-acids-dt20090813ptan20090203788.php Tue, 18 Aug 2009 22:49:07 -0700 This invention provides methods for improving reproductive performance of lactating dairy cows and other mammals. The method in the case of cows comprises feeding to the cows, a composition comprising conjugated linoleic acids (CLAs), cis-9, trans-11 and trans-10, cis-12. When these CLAs are fed daily to dairy cows starting at... http://www.freshpatents.com/Methods-and-composition-for-improving-cognitive-function-dt20090813ptan20090203786.php Tue, 18 Aug 2009 22:49:07 -0700 Compositions and methods for enhancing cognitive function in animals are disclosed. The compositions and methods utilize long chain polyunsaturated fatty acids.... http://www.freshpatents.com/Very-long-chain-polyunsaturated-fatty-acids-methods-of-production-and-uses-dt20090813ptan20090203787.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to processes for production of Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs). The present invention also relates to compositions (e.g., nutritional supplements and food products) containing such VLC-PUFAs. In one embodiment, the present invention is directed to methods for biosynthesis and production of the VLC-PUFAs described... http://www.freshpatents.com/Fast-dissolution-amino-acid-composition-dt20090813ptan20090203789.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention relates to oral dosage formulations for the rapid release of amino acids. A rapid release is achieved through the process of milling whereby the milled amino acids are more readily bioavailable.... http://www.freshpatents.com/Gamma-l-pga-producing-microorganism-method-of-producing-gamma-l-pga-using-the-microorganism-crosslinked-substance-produced-using-the-microorganism-and-external-dermal-agent-produced-using-the-microorganism-dt20090813ptan20090203790.php Tue, 18 Aug 2009 22:49:07 -0700 There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-γ-L-glutamate having large molecular weight by using the microorganism, and poly-γ-L-glutamate having an average... http://www.freshpatents.com/Methods-of-treating-non-painful-bladder-disorders-using-alpha2delta-subunit-calcium-channel-modulators-dt20090813ptan20090203792.php Tue, 18 Aug 2009 22:49:07 -0700 A method is provided for treatment of non-painful bladder disorders, particularly non-painful overactive bladder without loss of urine. The method comprises administration of an α2δ subunit calcium channel modulator, including gabapentin, pregabalin, GABA analogs, fused bicyclic or tricyclic amino acid analogs of gabapentin, amino acid compounds, and other compounds that... http://www.freshpatents.com/Nateglinide-containing-preparation-dt20090813ptan20090203791.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the nateglinide is amorphous.... http://www.freshpatents.com/Compounds-for-the-treatment-of-metabolic-disorders-dt20090813ptan20090203793.php Tue, 18 Aug 2009 22:49:07 -0700 Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed as Formula (I).... http://www.freshpatents.com/Aqueous-anaesthetic-composition-comprising-propofol-dt20090813ptan20090203794.php Tue, 18 Aug 2009 22:49:07 -0700 The invention discloses an aqueous anaesthetic Propofol composition that is stable, autoclave sterilized, suitable for parental administration, having reduced incidence of pain upon injection. The composition comprises propofol, 2-hydroxypropyl-β-cyclodextrin and a local anaesthetic, Lignocaine.... http://www.freshpatents.com/Polyquaternium-1-synthesis-methods-and-associated-formulations-dt20090813ptan20090203795.php Tue, 18 Aug 2009 22:49:07 -0700 A multipurpose solution for contact lens care, comprising: an aqueous liquid medium; a quaternary ammonium polymer having an average molecular weight as determined by the proton NMR method of at least 22 k, and methods for making.... http://www.freshpatents.com/Treatment-and-prevention-of-benign-breast-disease-with-4-hydroxy-tamoxifen-dt20090813ptan20090203796.php Tue, 18 Aug 2009 22:49:07 -0700 The present invention provides methods for treating and preventing benign breast disease by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts, 4-hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with benign breast disease, this effect induces disease regression. In patients at risk... http://www.freshpatents.com/Antimycotic-patch-dt20090813ptan20090203797.php Tue, 18 Aug 2009 22:49:07 -0700 A nail and/or skin patch for preventing or treating mycoses, which contains an antimycotic, having an octanol/water partition coefficient in the form of a logKo/w value of 4 or more, in a dissolved state in an acrylic-based pressure-sensitive adhesive layer or silicone-based pressure-sensitive adhesive layer. A nail and/or skin patch for... http://www.freshpatents.com/Solid-pharmaceutical-compositions-comprising-a-sip-receptor-agonist-and-a-sugar-alcohol-dt20090813ptan20090203798.php Tue, 18 Aug 2009 22:49:07 -0700 A solid pharmaceutical composition suitable for oral administration, comprising: (a) S 1 P receptor agonist; and (b) a sugar alcohol.... http://www.freshpatents.com/Novel-compositions-comprising-carotenoids-dt20090813ptan20090203799.php Tue, 18 Aug 2009 22:49:07 -0700 A novel composition for delivering carotenoids (e.g. α- and β-carotene, lycopene) and/or other physiologically active ingredients to the colon of humans after ingestion and for producing liquid food compositions insusceptible to polyphenol-protein reactions can be obtained by encapsulating said active ingredients with pectin, in particular with low-methoxylated pectin.... http://www.freshpatents.com/Cytostatic-composition-dt20090813ptan20090203800.php Tue, 18 Aug 2009 22:49:07 -0700 A cytostatic composition comprising an effective amount of an aldehyde in a pharmacological salt solution is shown to be effective at inhibiting growth of a number of cancerous cell lines.... http://www.freshpatents.com/Methods-of-inhibiting-ethylene-responses-in-plants-using-dicyclopropene-compounds-dt20090813ptan20090203801.php Tue, 18 Aug 2009 22:49:07 -0700 Methods of applying dicyclopropene compounds and compositions thereof to block ethylene receptors in plants are disclosed. Methods include applying to the plant an effective ethylene response-inhibiting amount of a dicyclopropene compound or composition thereof. Dicyclopropene compounds, enantiomers, stereoisomers or salts thereof are also provided.... http://www.freshpatents.com/Powder-composition-a-dispersion-of-powder-in-oil-and-a-cosmetic-comprising-the-same-dt20090813ptan20090203802.php Tue, 18 Aug 2009 22:49:07 -0700 and a powder and/or a coloring agent, a dispersion of powder in an oil in which the powder composition is dispersed, and cosmetics comprising the same, wherein each R1 is, independently, an organic group selected from the group consisting of C1-30 alkyl groups, aryl groups, aralkyl groups, fluorinated alkyl groups,... http://www.freshpatents.com/N-acylated-chitinous-polymers-and-methods-of-use-thereof-dt20090813ptan20090203803.php Tue, 18 Aug 2009 22:49:07 -0700 The invention pertains to N-acetylated, N, O-carboxyalkylchitosans and methods for using the chitosans to treat disorders, such as cancer, nervous system disorders, urinary tract disorders, and reproductive tract disorders....