http://www.freshpatents.com/Drug-bio-affecting-and-body-treating-compositions-dtnewntc514.php USPTO Class 514 - Drug, bio-affecting and body treating compositions en-us Wed, 30 Apr 2008 12:37:14 -0700 1000 Wednesday Thursday Friday Saturday Sunday 141 31 http://www.freshpatents.com/index.php?rss=true http://www.freshpatents.com/images/freshpatentsnav_rss.gif http://www.freshpatents.com/Peptide-and-a-derivative-thereof-promoting-cell-adhesion-and-spreading-dt20080424ptan20080096792.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-α3β1-dependent peptide in human laminin-5 α3 chain LG3 domain, mediating integrin α3β1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments and derivatives thereof can be used... http://www.freshpatents.com/Method-for-promoting-hard-tissue-formation-dt20080424ptan20080096798.php Wed, 30 Apr 2008 12:37:14 -0700 Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprising two proteins is administered to enhance biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension... http://www.freshpatents.com/Nitric-oxide-blocked-cross-linked-tetrameric-hemoglobin-dt20080424ptan20080096805.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the hemoglobin has a reduced ability to bind with nitric oxide. Preferably, the hemoglobin is deoxygenated, endotoxin free, and stroma free. The present invention also includes method... http://www.freshpatents.com/Cab-molecules-dt20080424ptan20080096810.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.... http://www.freshpatents.com/Diastereomeric-peptides-useful-as-inhibitors-of-membrane-protein-assembly-dt20080424ptan20080096809.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to membrane binding diastereomeric peptides comprising amino acid sequences corresponding to a fragment of a transmembrane proteins, wherein at least two amino acid residues of the diastereomeric peptides being in a D-isomer configuration. The diastereomeric peptides are useful in inhibiting fusion membrane protein events, including specifically... http://www.freshpatents.com/Selective-vpac2-receptor-peptide-agonists-dt20080424ptan20080096811.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention encompasses peptides that selectively activate the VPAC2 receptor and are useful in the treatment of diabetes.... http://www.freshpatents.com/Polytpeptide-specific-to-liver-cancer-polynucleotide-coding-for-the-polypeptide-and-rna-molecule-inhibiting--expression-of-the-polypeptide-dt20080424ptan20080096833.php Wed, 30 Apr 2008 12:37:14 -0700 There are provided a polypeptide specific to liver cancer, a polynucleotide coding for the polypeptide, and an RNA molecule suppressing the expression of the polypeptide. The present invention is particularly intended for a polypeptide comprising the amino acid sequence of SEQ ID NO: 1; a polypeptide having at least 80%... http://www.freshpatents.com/Calcium-phosphate-delivery-vehicles-for-osteoinductive-proteins-dt20080424ptan20080096797.php Wed, 30 Apr 2008 12:37:14 -0700 A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also... http://www.freshpatents.com/Class-iii-slrp-for-the-treatment-of-cancer-dt20080424ptan20080096793.php Wed, 30 Apr 2008 12:37:14 -0700 There is provided the use of an agent that promotes class III SLRP activity in the manufacture of a medicament for the prevention and/or treatment of cancer. Such medicaments may be used in the treatment of tumours, including avascular tumours. Suitable agents to be used may preferably include the class... http://www.freshpatents.com/Novel-antiangiogenic-peptide-agents-and-their-therapeutic-and-diagnostic-use-dt20080424ptan20080096795.php Wed, 30 Apr 2008 12:37:14 -0700 The current invention concerns novel antiangiogenic peptides which correspond to about 10 to about 150 consecutive amino acids of N-terminal sequences of human growth hormone, human placental lactogen, human growth hormone variant hGH-V, and prolactin, and their use in inhibiting angiogenesis and in the diagnosis of diseases of human pregnancy... http://www.freshpatents.com/Peptide-mixture-from-peptides-having-a-molecular-weight-of-from-1000-to-5000-dalton-dt20080424ptan20080096794.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to the use of a peptide mixture comprising peptides with a molecular weight from 1000 to 5000 Daltons for the prevention and/or treatment of tumour diseases, of diseases which are associated with a development disorder of the immune system, of diseases of the immune system, of autoimmune... http://www.freshpatents.com/Peptides-that-stimulate-cell-survival-and-axon-regeneration-dt20080424ptan20080096796.php Wed, 30 Apr 2008 12:37:14 -0700 Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa (SEQ.ID.NO.: 1) in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any amino acid, Xaa at position 3 represents any amino acid and Xaa at position 4 represents Glu or Asp, each... http://www.freshpatents.com/Compositions-and-methods-for-the-prevention-and-control-of-insulin-induced-hypoglycemia-dt20080424ptan20080096801.php Wed, 30 Apr 2008 12:37:14 -0700 Pharmaceutical composition comprising both insulin and glucagon can be administered to control and treat diabetes while reducing or eliminating the risk of insulin-induced hypoglycemia.... http://www.freshpatents.com/Compounds-for-and-methods-of-treating-insulin-resistance-and-inflammation-dt20080424ptan20080096799.php Wed, 30 Apr 2008 12:37:14 -0700 Novel compounds, compositions comprising compounds, and methods for preparing and using compounds are described herein. Methods of treating or ameliorating various conditions, including insulin resistance, pancreatic beta cell apoptosis, obesity, pro-thrombotic conditions, myocardial infarction, hypertension, dyslipidemia, manifestations of Syndrome X, congestive heart failure, inflammatory disease of the cardiovascular system, atherosclerosis,... http://www.freshpatents.com/Rapid-mucosal-gel-or-film-insulin-compositions-dt20080424ptan20080096800.php Wed, 30 Apr 2008 12:37:14 -0700 Gel, powder, suspension, emulsions or film formulations for systemic delivery of insulin with improved stability and rapid onset of action are described herein. The formulations are preferably absorbed to a mucosal surface, most preferably via buccal or sublingual administration, although rectal, vaginal, nasal or ocular administration is possible. The formulations... http://www.freshpatents.com/Combination-therapy-comprising-glucose-reabsorption-inhibitors-and-ppar-modulators-dt20080424ptan20080096802.php Wed, 30 Apr 2008 12:37:14 -0700 Combination therapy comprising PPAR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.... http://www.freshpatents.com/Carboxymethylated-cross-linked-tetrameric-hemoglobin-dt20080424ptan20080096803.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention includes compositions containing carboxymethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes thiol protecting group and where the hemoglobin is incapable of binding with the nitric oxide. Preferably, the hemoglobin is deoxygenated, endotoxin free, and stroma free. The present invention also includes method of preparation,... http://www.freshpatents.com/Pure-amino-acid-chelate-complexes-and-uses-thereof-dt20080424ptan20080096804.php Wed, 30 Apr 2008 12:37:14 -0700 A two-stage method of preparing essentially pure amino acid chelates, wherein the first stage comprises contacting a metal ion from a metal oxide or hydroxide with an amino acid thereby producing a metal hydroxyl amino acetate. The second stage comprises contacting the metal hydroxyl amino acetate from the first stage,... http://www.freshpatents.com/Compositions-and-methods-for-inhibiting-microbial-adhesion-dt20080424ptan20080096806.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides compositions and methods for treating or preventing microbial infections.... http://www.freshpatents.com/Cyclic-vasoactive-intestinal-peptide-receptor-2-agonists-dt20080424ptan20080096807.php Wed, 30 Apr 2008 12:37:14 -0700 or a pharmaceutically acceptable salt thereof. Underlined residues indicate a side-chain to side-chain covalent linkage of the first and last amino acids within the segment. The present invention also encompasses pharmaceutical compositions containing such agonists, and the use of such agonists for the treatment of pulmonary diseases including COPD. The... http://www.freshpatents.com/Use-of-rapamycin-to-inhibit-response-and-induce-tolerance-to-gene-therapy-vector-and-encoded-transgene-products-dt20080424ptan20080096808.php Wed, 30 Apr 2008 12:37:14 -0700 Disclosed are methods for transient co-administration of rapamycin together with a gene therapy vector encoding a transgene. The present invention is directed to inhibiting the immune response of a host to the administered gene therapy vector and encoded trans gene product, thus allowing persistent trans gene expression and repeated administration... http://www.freshpatents.com/Amino-acid-substituted-molecules-dt20080424ptan20080096819.php Wed, 30 Apr 2008 12:37:14 -0700 The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also... http://www.freshpatents.com/Cytostatin-ii-dt20080424ptan20080096821.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in... http://www.freshpatents.com/Generation-of-potent-dominant-negative-transcriptional-inhibitors-dt20080424ptan20080096813.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides methods and compositions for regulating gene expression using transcription factors linked to proteins that localize to the transcriptional machinery.... http://www.freshpatents.com/Methods-of-treating-disorders-of-the-eye-and-surrounding-tissue-with-thymosin-beta-4--tbeta4--analogues-isoforms-and-other-derivatives-dt20080424ptan20080096817.php Wed, 30 Apr 2008 12:37:14 -0700 Eye degradation such as may be associated with dry eye syndrome is inhibited or reversed by administration of an actin-sequestering peptide such as Thymosin β4, an isoform of Thymosin β4 or oxidized Thymosin β4.... http://www.freshpatents.com/Orally-administered-peptides-synergize-statin-activity-dt20080424ptan20080096814.php Wed, 30 Apr 2008 12:37:14 -0700 This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention... http://www.freshpatents.com/Orally-administered-peptides-synergize-statin-activity-dt20080424ptan20080096815.php Wed, 30 Apr 2008 12:37:14 -0700 This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention... http://www.freshpatents.com/Orally-administered-peptides-synergize-statin-activity-dt20080424ptan20080096816.php Wed, 30 Apr 2008 12:37:14 -0700 This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are highly stable and readily administered via an oral route. The peptides are effective to stimulate the formation and cycling of pre-beta high density lipoprotein-like particles and/or to promote lipid transport and detoxification. This invention... http://www.freshpatents.com/Prevention-and-treatment-of-amyloidogenic-disease-dt20080424ptan20080096818.php Wed, 30 Apr 2008 12:37:14 -0700 The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease.... http://www.freshpatents.com/Prodomain-modulators-of-adam-10-dt20080424ptan20080096820.php Wed, 30 Apr 2008 12:37:14 -0700 The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases such as cancer, neurological disorders, asthma, and allergic responses, and disorders characterized at least in part by the presence of one... http://www.freshpatents.com/Use-of-the-neurotoxic-component-of-a-botulinum-toxin-dt20080424ptan20080096822.php Wed, 30 Apr 2008 12:37:14 -0700 A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.... http://www.freshpatents.com/Water-soluble-elastin-process-for-producing-same-and-food-and-medicine-containing-same-dt20080424ptan20080096812.php Wed, 30 Apr 2008 12:37:14 -0700 A low-molecular-weight water-soluble elastin having a molecular weight of about 10,000 to 30,000 and a high-molecular-weight water-soluble elastin having a molecular weight of about 30,000 to 300,000 are provided, 79% to 84% of the constituent amino acids of the elastin comprising proline, glycine, alanine, and valine, 2% to 3% comprising... http://www.freshpatents.com/Neurotensin-receptor-agonists-and-opioid-receptor-agonists-dt20080424ptan20080096823.php Wed, 30 Apr 2008 12:37:14 -0700 This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR agonist in combination with an opioid receptor agonist also are provided.... http://www.freshpatents.com/Ku-70-derived-bax-suppressing-peptides-and-use-thereof-for-the-protection-of-damaged-cells-dt20080424ptan20080096824.php Wed, 30 Apr 2008 12:37:14 -0700 A method of protecting cells from cell death comprising the step of supplying to the cell an effective amount of a Bax-inhibiting peptide is disclosed.... http://www.freshpatents.com/Preparation-and-use-of-phlorizin-compositions-dt20080424ptan20080096825.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention concerns the isolation of phlorizin from plants of the genus Lithocarpus, phlorizin-containing compositions and their uses.... http://www.freshpatents.com/Formulation-of-a-mixture-of-free-b-ring-flavonoids-and-flavans-for-use-in-the-prevention-and-treatment-of-cognitive-decline-and-age-related-memory-impairments-dt20080424ptan20080096826.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides a novel method for preventing and treating memory and cognitive impairment resulting from oxidative stress, inflammation and the process of aging, as well as, neurodegenerative conditions. The method is comprised of administering a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from... http://www.freshpatents.com/Formulation-of-a-mixture-of-free-b-ring-flavonoids-and-flavans-for-use-in-the-prevention-and-treatment-of-cognitive-decline-and-age-related-memory-impairments-dt20080424ptan20080096827.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides a novel method for preventing and treating memory and cognitive impairment resulting from oxidative stress, inflammation and the process of aging, as well as, neurodegenerative conditions. The method is comprised of administering a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from... http://www.freshpatents.com/7-quinolyl-ketolide-antibacterial-agents-dt20080424ptan20080096828.php Wed, 30 Apr 2008 12:37:14 -0700 having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections. 15-fluoroketolides of the formula... http://www.freshpatents.com/Anti-inflammatory-macrolide-conjugates-dt20080424ptan20080096830.php Wed, 30 Apr 2008 12:37:14 -0700 wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, D represents a dibenzo[e,h]azulene subunit with anti-inflammatory, analgesic and/or antipyretic activity and L represents a linking group covalently linking M and D; (b) to their pharmacologically acceptable salts, prodrugs and solvates,... http://www.freshpatents.com/Macrolone-compounds-dt20080424ptan20080096829.php Wed, 30 Apr 2008 12:37:14 -0700 For use as antibacterial agents, compositions containing same, processes for their preparation and their use in therapy. A compound of formula (I)... http://www.freshpatents.com/Method-for-improving-the-pharmacokinetics-of-an-nnrti-dt20080424ptan20080096832.php Wed, 30 Apr 2008 12:37:14 -0700 An improved method for using a NNRTI in the treatment of HIV-1 infection, comprising administering to a human, needing treatment for HIV-1 infection, a therapeutically effective amount of said NNRTI or a pharmaceutically acceptable salt thereof, and an amount of an inhibitor of the cytochromes P450 that is sufficient to... http://www.freshpatents.com/Stabilized-azithromycin-composition-dt20080424ptan20080096831.php Wed, 30 Apr 2008 12:37:14 -0700 A stabilized azithromycin composition comprising azithromycin monohydrate, and about 5 to about 15 weight percent, based on the total weight of the composition, of water. The present inventors have unexpectedly determined that a certain amount of water is necessary to stabilize a pharmaceutical composition comprising azithromycin monohydrate. In addition, the... http://www.freshpatents.com/Anti-tumor-activity-of-ea-4-peptide-of-pro-igf-i-dt20080424ptan20080096834.php Wed, 30 Apr 2008 12:37:14 -0700 Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.... http://www.freshpatents.com/Defective-sindbis-viral-vectors-dt20080424ptan20080096837.php Wed, 30 Apr 2008 12:37:14 -0700 Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are plasmids used for the production of the vectors, methods for... http://www.freshpatents.com/Guanosine-rich-oligonucleotides-and-methods-of-inducing-apoptosis-in-tumor-cells-dt20080424ptan20080096838.php Wed, 30 Apr 2008 12:37:14 -0700 Presently described is a guanosine-rich polynucleotide molecule with therapeutic utility for treating or preventing the growth of cancerous cells. In addition, a method of retarding cell cycle progression and inducing apoptosis in tumor cells using synthetic oligonucleotides is also described.... http://www.freshpatents.com/Inhibitory-oligonucleotides-targeted-to-bcl-2-dt20080424ptan20080096835.php Wed, 30 Apr 2008 12:37:14 -0700 Inhibitory oligonucleotides are disclosed which are targeted to three specific target regions and subsequences of the target regions found on nucleic acids encoding Bcl-2. These inhibitory oligonucleotides are generally of from about 8 to about 50 nucleotides in length. Specific preferred oligonucleotides are disclosed. The oligonucleotides of the invention may... http://www.freshpatents.com/Kinase-supressor-of-ras-inactivation-for-therapy-of-ras-mediated-tumorigenesis-dt20080424ptan20080096840.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid... http://www.freshpatents.com/Screening-method-dt20080424ptan20080096836.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to methods for the identification of novel receptors and/or novel ligands. The invention is based on the concept that parasites have developed a number of biologically active compounds in their saliva to cope with the defense mechanisms of the host organisms on which they feed and to... http://www.freshpatents.com/Small-interfering-rna-and-pharmaceutical-composition-for-treatment-of-hepatitis-b-comprising-the-same-dt20080424ptan20080096839.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to RNA interference mediated inhibition of Hepatitis B virus (HBV) by short interfering RNA (siRNA) molecules. Specially, siRNAs of the present invention which are double-stranded RNAs concern directing the sequence-specific degradation of viral RNA in mammalian cells. Disclosed is a DNA vector encoding the RNA molecules... http://www.freshpatents.com/Treatment-and-prevention-of-heat-shock-protein-associated-diseases-and-conditions-dt20080424ptan20080096841.php Wed, 30 Apr 2008 12:37:14 -0700 The invention provides methods of treating and preventing heat shock protein-associated diseases and conditions.... http://www.freshpatents.com/Preventive-remedy-for-obesity-dt20080424ptan20080096842.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to raw materials for pharmaceuticals and the like, wherein the raw materials can be effective in preventing and remedying various lifestyle-related diseases such as obesity and hyperlipidemia, safe, and applicable in wide areas; and the present invention also relates to a preventive/remedy for obesity, an agent... http://www.freshpatents.com/Substituted-isoxazoles-as-fungicides-dt20080424ptan20080096843.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides compounds of formula I: (I) along with methods of making the same, compositions thereof, and methods of use thereof, particularly methods of use as fungicides.... http://www.freshpatents.com/Novel-inhibitors-of-chymase-dt20080424ptan20080096844.php Wed, 30 Apr 2008 12:37:14 -0700 or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and compositions, intermediates and derivatives thereof, and methods for treating inflammatory or serine protease mediated disorders. The present invention is directed to a compound of Formula (I):... http://www.freshpatents.com/Sphingomyelin-therapy-of-autoimmune-disease-dt20080424ptan20080096845.php Wed, 30 Apr 2008 12:37:14 -0700 Autoimmune disease therapy in a patient treated with apoptosis-inducing agents is enhanced by co-administration of sphingomyelin. The combination most likely enhances an autoimmune disease cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby providing sufficient substrate for activated sphingomyelinase. In alternative embodiments,... http://www.freshpatents.com/Arene-ruthenium--ll--compounds-and-their-use-in-cancer-therapy-dt20080424ptan20080096846.php Wed, 30 Apr 2008 12:37:14 -0700 A ruthenium (II) compound of formula (I): or a solvate on prodrug thereof, wherein: R1, R1, R3, R4, R5 and R6 are independently selected from H, C1-7 alkyl, C5-20 aryl, C3-20 heterocyclyl, halo, ester, amido, acyl, sulfo, sulfonamido, ether, thioether, azo, amino, or R1 and R2 together with the ring... http://www.freshpatents.com/Composition-and-method-for-inducing-or-restoring-locomotor-functions-in-an-animal-dt20080424ptan20080096847.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to the field of neuropathological disorders involving impaired locomotor functions. More specifically, the present invention relates to a composition and method for inducing and restoring locomotor functions, such as basic walking movements in the lower extremities of chronic spinal cord injured animals, such as paraplegic or... http://www.freshpatents.com/Formulations-and-uses-of-2-hydroxy-5-phenylazobenzoic-acid-derivatives-dt20080424ptan20080096849.php Wed, 30 Apr 2008 12:37:14 -0700 A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of balsalazide in a suitable container and associated with printed labeling which describes the increased bioavailability of the medication... http://www.freshpatents.com/Substituted-n-aryl-9-oxo-9h-fluorene-1-carboxamides-and-analogs-as-activators-of-caspases-and-inducers-of-apoptosis-dt20080424ptan20080096848.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention is directed to substituted N-aryl-9-oxo-9H-fluorene-1-carboxamides and analogs thereof, represented by the general Formula I: (I) wherein R1-R8, X and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators... http://www.freshpatents.com/Methods-for-inhibiting-the-production-of-tsst-1-dt20080424ptan20080096850.php Wed, 30 Apr 2008 12:37:14 -0700 Methods for inhibiting the production of TSST-1 from Gram positive bacteria are disclosed. The methods comprise exposing the Gram positive bacteria to compounds capable of inhibiting the production of TSST-1 from the Gram positive bacteria.... http://www.freshpatents.com/-20s--1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol-and-its-uses-dt20080424ptan20080096851.php Wed, 30 Apr 2008 12:37:14 -0700 This invention discloses (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such... http://www.freshpatents.com/Use-of-oculosurface-selective-glucocorticoid-in-the-treatment-of-dry-eye-dt20080424ptan20080096852.php Wed, 30 Apr 2008 12:37:14 -0700 Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of... http://www.freshpatents.com/Composition-and-method-for-treating-or-preventing-gastrointestinal-cancer-dt20080424ptan20080096854.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides novel compositions and methods for repair and regeneration of tissues or organs of the body, especially mucosa in the gastrointestinal tract. The composition can be used as a pharmaceutical or nutraceutical to treat or prevent gastrointestinal cancer such as colorectal carcinoma, stomach cancer and esophagus cancer.... http://www.freshpatents.com/Edible-compositions-comprising-a-primary-lipid-a-co-lipid-a-lipohilic-physiologically-active-ingredient-and-water-and-their-preparation-dt20080424ptan20080096853.php Wed, 30 Apr 2008 12:37:14 -0700 A composition comprising: a) a primary lipid component obtainable as the reaction product of one or more carboxylic acids with at least one of glycerol and propylene glycol; b) a co-lipid component selected from at least one of phosphorus-containing lipids and hydroxylated carboxylic acid esters of mono- and di-glycerides; c)... http://www.freshpatents.com/Process-for-obtaining-norelgestromin-in-different-relations-of-isomers-e-and-z-dt20080424ptan20080096855.php Wed, 30 Apr 2008 12:37:14 -0700 and the method of producing the oxime. The present invention is related to an oxime of the 13β-ethyl-17α-hydroxi-18,19-dinorpregn-4-en-20-in-3-o (norelgestromin) of Formula I with a relation of isomers E/Z between 1.3 and 1.6... http://www.freshpatents.com/Antibiotic-compound-dt20080424ptan20080096856.php Wed, 30 Apr 2008 12:37:14 -0700 Fermentation of a nutrient medium with a Nocardia spp. yields a novel broad spectrum antibiotic compound of structural formula (I) or a pharmaceutically acceptable salt, ester, enantiomer, diasteriomer or mixture.... http://www.freshpatents.com/Photodynamic-therapy-for-the-treatment-of-hyperactive-sebaceous-gland-disorders-using-topically-applied-hydrophobic-green-porphyrins-dt20080424ptan20080096857.php Wed, 30 Apr 2008 12:37:14 -0700 The present method involves the photodynamic treatment of hyperactive gland disorders. The method involves the topical administration of a photosensitizer composition comprising hydrophobic and/or lipophilic green porphyrins such as lemuteporfin, polyethylene glycol and skin penetration enhancers such as oleyl alcohol and TRANSCUTOL™ to affected skin and subsequent exposure of that... http://www.freshpatents.com/Method-of-stabilizing-disordered-cefovecin-sodium-salt-dt20080424ptan20080096858.php Wed, 30 Apr 2008 12:37:14 -0700 A method of stabilizing pharmaceutical compositions containing cefovecin sodium salt which is in an amorphous or other disordered state is disclosed.... http://www.freshpatents.com/Compositions-and-methods-for-treating-ophthalmic-diseases-dt20080424ptan20080096859.php Wed, 30 Apr 2008 12:37:14 -0700 This invention relates to CXCR4 inhibitors and their use in treating and/or preventing a variety of angiogenic, microvascular and ocular disorders including primary indications for diabetic retinopathy, macular degeneration (such as wet or neovascular age-related macular degeneration (AMD) and dry or atrophic AMD), macular edema, and secondary indications for inhibiting... http://www.freshpatents.com/Pyrimidine-sulphonamide-derivatives-as-chemokine-receptor-modulators-dt20080424ptan20080096860.php Wed, 30 Apr 2008 12:37:14 -0700 A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of chemokine mediated diseases and disorders.... http://www.freshpatents.com/Chemical-compounds-dt20080424ptan20080096861.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a target cell.... http://www.freshpatents.com/Stable-pharmaceutical-compositions-of-calcium-channel-blocker-and-an-ace-inhibitor-dt20080424ptan20080096863.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to a stable pharmaceutical composition of a combination of amlodipine and an ACE inhibitor; wherein the two active ingredients are not physically separated and the composition has a pH of more than 6.0. It also relates to a process for preparation, and a method for using... http://www.freshpatents.com/Treatment-of-gastrointestinal-stromal-tumors-with-imatinib-and-midostaurin-dt20080424ptan20080096864.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to the use of a combination comprising (a) imatinib or a pharmaceutically acceptable salt thereof and midostaurin or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment of gastrointestinal stromal tumors, e.g. imatinib-resistant gastro-intestinal stromal tumors.... http://www.freshpatents.com/Method-for-treating-neovascularization-dt20080424ptan20080096865.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention describes an improved photodynamic treatment to treat subfoveal choroidal neovascularization (CNV).... http://www.freshpatents.com/Complex-formulation-of-3-hydroxy-3-methyl-glutaryl-coa-reductace-inhibitor-and-antihypertensive-agent-and-process-for-preparing-same-dt20080424ptan20080096866.php Wed, 30 Apr 2008 12:37:14 -0700 A complex formulation for oral administration comprising a sustained release formulation of an HMG-CoA reductase inhibitor and a film layer for rapid release of an anti-hypertensive agent, the film layer being coated on the sustained release formulation, can achieve improved therapeutic effects of the anti-hypertensive agent by promptly releasing it,... http://www.freshpatents.com/Lactam-compounds-and-pharmaceutical-use-thereof-dt20080424ptan20080096862.php Wed, 30 Apr 2008 12:37:14 -0700 An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.... http://www.freshpatents.com/Complex-formulation-of-3-hydroxy-3-methyl-glutaryl-coa-reductace-inhibitor-and-antihypertensive-agent-and-process-for-preparing-same-dt20080424ptan20080096867.php Wed, 30 Apr 2008 12:37:14 -0700 are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A representative compound of the invention is: Imidazo[1,2-a]pyridines of the formulae I and II:... http://www.freshpatents.com/14-substituted-pyrazolopyrimidines-as-kinase-inhibitors-dt20080424ptan20080096868.php Wed, 30 Apr 2008 12:37:14 -0700 pharmaceuticals comprising a 1,4-substituted pyrazolopyrimidine compound, the use of a 1,4-substituted pyrazolopyrimidine compound in the treatment or the use thereof in the manufacture of a pharmaceutical formulation for the treatment of a disease that depends on inadequate activity of a protein kinase, methods of treatment comprising administering a 1,4-substituted pyrazolopyrimidine... http://www.freshpatents.com/Adamantyl-acetamides-as-11-beta-hydroxysteroid-dehydrogenase-inhibitors-dt20080424ptan20080096869.php Wed, 30 Apr 2008 12:37:14 -0700  wherein said C6-12cycloalkyl or monovalent radical may optionally be substituted with one, or where possible two, three or more substituents selected from the group consisting of C1-4alkyl, C1-4alkyloxy, halo or hydroxy; Q represents Het1 or Ar2 wherein said C3-8cycloalkyl, Het1 or Ar2 are optionally substituted with one or where possible... http://www.freshpatents.com/Methods-and-materials-for-treating-mental-illness-dt20080424ptan20080096870.php Wed, 30 Apr 2008 12:37:14 -0700 The subject invention pertains to methods of treating mental illnesses or conditions characterized by a decreased function of NMDA receptors and/or excessively enhanced glutamate release and activity of non-NMDA receptors (AMPA and/or kainate). Specifically disclosed are methods utilizing BrPhe, or isomers of analogs thereof, for treating or preventing mental illness... http://www.freshpatents.com/Composition-for-treatment-of-pain-specification-dt20080424ptan20080096872.php Wed, 30 Apr 2008 12:37:14 -0700 A method for the treatment of pain and/or inflammation in a subject by the administration of N-acetyl-cysteine (NAC) or derivative thereof and a pain and/or anti-inflammatory medication. The pain or anti-inflammatory medication is metabolized by the action of the cytochrome p450 system. The pain medication includes N-methyl-D-aspartate (NMDA) receptor antagonist(s).... http://www.freshpatents.com/Olanzapine-pamoate-dihydrate-dt20080424ptan20080096871.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates olanzapine pamoate dihydrate, pharmaceutical compositions thereof and use in treating certain mental disorders, such as schizophrenia.... http://www.freshpatents.com/New-compounds-dt20080424ptan20080096873.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.... http://www.freshpatents.com/Oxadiazole-derivative-as-dgat-inhibitors-dt20080424ptan20080096874.php Wed, 30 Apr 2008 12:37:14 -0700 Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example R1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; R2 is an optionally substituted aryl, an optionally substituted cycloalkyl or an... http://www.freshpatents.com/Thiourea-compounds-dt20080424ptan20080096875.php Wed, 30 Apr 2008 12:37:14 -0700 Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection. This invention relates to thiourea compounds of formula (II) shown below:... http://www.freshpatents.com/Phenylalkynes-dt20080424ptan20080096876.php Wed, 30 Apr 2008 12:37:14 -0700 Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.... http://www.freshpatents.com/Indole-compound-dt20080424ptan20080096877.php Wed, 30 Apr 2008 12:37:14 -0700 wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof. R2 is a group represented by R1 is a hydrogen atom or a halogen atom; wherein The present invention provides a glucokinase activator containing a... http://www.freshpatents.com/Bicyclic-anilide-spirolactam-cgrp-receptor-antagonists-dt20080424ptan20080096878.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention is directed to compounds of Formula (I): (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such... http://www.freshpatents.com/Synthesis-of-fr901464-and-analogs-with-antitumor-activity-dt20080424ptan20080096879.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.... http://www.freshpatents.com/Novel-use-of-imidazotriazinones-dt20080424ptan20080096880.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to novel uses of imidazo[1,2,4]triazinones for producing a medicament for the treatment and/or prophylaxis of coronary cardiopathy, heart failure, pulmonary hypertension, bladder complaints, prostatic hyperplasia, nitrate-induced tolerance, or diseases of the eye, such as glaucoma, for the treatment or prophylaxis of central, retinal or posterior ciliary artery... http://www.freshpatents.com/Quinazoline-derivatives-dt20080424ptan20080096881.php Wed, 30 Apr 2008 12:37:14 -0700 The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, X1, R2, R3, R5, n and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative... http://www.freshpatents.com/Dihydrothienopyrimidines-for-the-treatment-of-inflammatory-diseases-dt20080424ptan20080096882.php Wed, 30 Apr 2008 12:37:14 -0700 and which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds. wherein X is SO or SO2, but preferably SO,... http://www.freshpatents.com/Trifluoromethyl-substituted-benzamides-as-kinase-inhibitors-dt20080424ptan20080096883.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative... http://www.freshpatents.com/4-aminoquinoline-3-carboxamide-derivatives-as-pde4-inhibitors-dt20080424ptan20080096884.php Wed, 30 Apr 2008 12:37:14 -0700 or pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type IV (PDE4) and are of use in the treatment of inflammatory and/or allergic diseases. Compounds of formula (I)... http://www.freshpatents.com/Benzene-pyridine-and-pyridazine-derivatives-dt20080424ptan20080096887.php Wed, 30 Apr 2008 12:37:14 -0700 wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions... http://www.freshpatents.com/Process-for-the-manufacture-of-3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-14-dihydropyridine-2-carboxamide-and-its-related-analogues-dt20080424ptan20080096886.php Wed, 30 Apr 2008 12:37:14 -0700 The process includes reacting an amine R2NH2 with a compound of formula II in a solution of metal hydroxide in water to give a compound of formula III. Subsequent reaction of the compound of formula III with an acid chloride formation reagent in an inert solvent gives compounds of formula... http://www.freshpatents.com/Quinoline-derivatives-as-neurokinin-receptor-antagonists-dt20080424ptan20080096885.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to substituted quinoline-4-carboxylic acid hydrazides defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors.... http://www.freshpatents.com/Novel-compounds-as-opioid-receptor-modulators-dt20080424ptan20080096888.php Wed, 30 Apr 2008 12:37:14 -0700 The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors. The present invention is directed to novel opioid receptor modulators of Formula (I).... http://www.freshpatents.com/Histone-deacetylases-inhibitors-dt20080424ptan20080096889.php Wed, 30 Apr 2008 12:37:14 -0700 where R1 is a linear or branched chain containing at least two conjugated double bonds, A is an optionally substituted phenyl or pyridyl ring, Ar is an aryl or heteroaryl group, and R3 is hydrogen or alkoxyalkyl. The application also describes the use of said compounds in the treatment of... http://www.freshpatents.com/Highly-selective-norepinephrine-reuptake-inhibitors-and-methods-of-using-the-same-dt20080424ptan20080096890.php Wed, 30 Apr 2008 12:37:14 -0700 Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about... http://www.freshpatents.com/Triazine-derivatives-their-preparation-and-therapeutic-application-thereof-dt20080424ptan20080096891.php Wed, 30 Apr 2008 12:37:14 -0700 Wherein R1, R2 and R3 are as defined herein. The invention also relates to a method for preparing these triazine derivatives and to the therapeutic application thereof. The invention relates to triazine derivatives of general formula (I):... http://www.freshpatents.com/C-kit-modulators-and-methods-of-use-dt20080424ptan20080096892.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellu-lar activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention provides compounds for modulating c-Kit kinase activity and methods of treating diseases mediated by c-Kit activity utilizing the compounds and... http://www.freshpatents.com/Aminopterin-dosage-forms-dt20080424ptan20080096893.php Wed, 30 Apr 2008 12:37:14 -0700 Embodiments of the present invention provide dosage forms and methods for treating a patient with an inflammatory disorder with a therapeutically effective amount of aminopterin, or a pharmaceutically acceptable salt thereof, that achieve efficacy without concomitant toxicity. Within certain embodiments, the present invention provides a method for treating an inflammatory... http://www.freshpatents.com/Heterocyclic-derivatives-and-their-use-as-stearoyl-coa-desaturase-inhibitors-dt20080424ptan20080096895.php Wed, 30 Apr 2008 12:37:14 -0700 where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed. Methods of treating an SCD-mediated disease or... http://www.freshpatents.com/Anti-bacterial-compounds-dt20080424ptan20080096894.php Wed, 30 Apr 2008 12:37:14 -0700 Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).... http://www.freshpatents.com/Cyclic-amide---x26--ester-pyrazinoylganidine-sodium-channel-blockers-dt20080424ptan20080096896.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.... http://www.freshpatents.com/5--11-biphenyl--4-yl-5--4--4-aminoacylphenyl--piperazin--1-yl-pyrimidine-246-trione-derivatives-as-inhibitors-of-zinc-metallondopeptidases-their-preparation-and-use-dt20080424ptan20080096897.php Wed, 30 Apr 2008 12:37:14 -0700 New Pyrimidinetrione derivatives represented by formula (I), wherein R1 and R2 are defined in the description, composition thereof, and methods of preparation are described. The compounds are useful in the treatment of disease involving metalloproteinases.... http://www.freshpatents.com/Organic-compounds-dt20080424ptan20080096898.php Wed, 30 Apr 2008 12:37:14 -0700 in free or salt form, wherein Ar, R1, R2, R3, X and T have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3, particularly an inflammatory or allergic condition such as an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds... http://www.freshpatents.com/Methods-for-treating-atherosclerosis-dt20080424ptan20080096900.php Wed, 30 Apr 2008 12:37:14 -0700 The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.... http://www.freshpatents.com/N-phenyl-2-pyrimidine-amine-derivatives-and-process-for-the-preparation-thereof-dt20080424ptan20080096899.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to a novel N-phenyl-2-pyrimidine-amine derivative represented by the above formula (1) and its salt showing a superior effect on cancer in warm-blooded animals, such as lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder... http://www.freshpatents.com/Aminotriazole-compounds-useful-as-inhibitors-of-protein-kinases-dt20080424ptan20080096901.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.... http://www.freshpatents.com/Biomimetic-of-evodia-rutaecarpa-fruit-extract-for-amelioration-of-inflammation-dt20080424ptan20080096902.php Wed, 30 Apr 2008 12:37:14 -0700 Compositions and methods are provided for reversing and/or inhibiting inflammation, e.g., by inhibiting prostaglandin and/or COX-2 production, using one or more indolequinazoline alkaloids, preferably in combination with butylated hydroxytoluene. The preferred indolequinazoline alkaloids are rutaecarpine, evodiamine, and dehydroevodiamine, which are naturally found in unpurified form in the traditional Chinese medicine... http://www.freshpatents.com/Sulfamoyl-containing-derivatives-and-uses-thereof-dt20080424ptan20080096903.php Wed, 30 Apr 2008 12:37:14 -0700 Sulfamoyl-containing compounds are disclosed, having utility as inhibitors of disease-related targets, such as Heat Shock Protein 90 (HSP90), and which are useful for treating disorders, e.g., proliferative disorders, including HSP90-mediated disorders. Methods for preparing and using the disclosed compounds are also described.... http://www.freshpatents.com/Compositions-and-methods-for-treatment-and-prevention-of-insulin-resistance-dt20080424ptan20080096904.php Wed, 30 Apr 2008 12:37:14 -0700 Disclosed herein are methods of delaying the onset or treating diabetes that comprises administering a uric acid lowering agent. The inventors have made the remarkable discovery that elevated uric acid levels are not a corollary to insulin resistance, but rather a primary mediator of insulin resistance. Specifically exemplified are methods... http://www.freshpatents.com/Process-for-preparing-pyrido-23-d-pyrimidin-7-one-and-34-dihydropyrimido-45-d-pyrimidin-2-1h--one-derivatives-dt20080424ptan20080096905.php Wed, 30 Apr 2008 12:37:14 -0700 Rg is a C1-10alkyl; with a olefin forming reagent in a suitable base to yield a compound of Formula (II), wherein m=0 and oxidizing the sulphur as necessary or desired. Ry is chloro, bromo, iodo, O—S(O)2CF3; and wherein which comprises reacting a compound of the formula:... http://www.freshpatents.com/Aminomethyl-2-imidazoles-dt20080424ptan20080096906.php Wed, 30 Apr 2008 12:37:14 -0700 —(CR2)m-heteroaryl; each R is selected from the group consisting of hydrogen, lower alkyl and hydroxy; Ar is selected from the group consisting of phenyl, pyrimidin-2-yl, pyrimidin-4-yl and pyridin-3-yl; n is 0, 1 or 2; x is 0, 1, 2 or 3; m is 0 or 1; and to their pharmaceutically... http://www.freshpatents.com/Aryl-pyrimidyl-compounds-pharmaceutical-compositions-comprising-them-their-use-as-antimicrobial-agents-dt20080424ptan20080096907.php Wed, 30 Apr 2008 12:37:14 -0700 Substituted aryl pyrimidyl compounds responding to formula (I) and their use for the preparation of a medicament for the prevention and/or treatment of a pathology caused by a mycobacteria.... http://www.freshpatents.com/Statin-derivatives-dt20080424ptan20080096908.php Wed, 30 Apr 2008 12:37:14 -0700 Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.... http://www.freshpatents.com/Apomorphine-inhibitors-of-amyloid-beta--abeta--fibril-formation-and-their-use-in-amyloidosis-based-disease-dt20080424ptan20080096909.php Wed, 30 Apr 2008 12:37:14 -0700 Described is a new class of small molecule inhibitors of amyloid β protein (Aβ) aggregation, based on apomorphine. These molecules target the nucleation phase of Aβ self-assembly and interfere effectively with aggregation of Aβ 1-40 into amyloid fibrils in vitro as determined by transmission electron microscopy, Thioflavin T (ThT) fluorescence,... http://www.freshpatents.com/Rapid-release-mini-tablets-provide-analgesia-in-laboratory-animals-dt20080424ptan20080096910.php Wed, 30 Apr 2008 12:37:14 -0700 Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg cholesterol-tryglyceride-buprenorphine pellets released the majority of drug in 24-48 hours after implant and provide clinically significant plasma levels of analgesia in... http://www.freshpatents.com/Compounds-having-beta2-adrenergic-receptor-agonist-and-muscarinic-receptor-antagonist-activity-dt20080424ptan20080096911.php Wed, 30 Apr 2008 12:37:14 -0700 wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1, G2, a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds;... http://www.freshpatents.com/Indole-azaindole-and-related-heterocyclic-pyrrolidine-derivatives-dt20080424ptan20080096912.php Wed, 30 Apr 2008 12:37:14 -0700 This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the... http://www.freshpatents.com/Ppar-active-compounds-dt20080424ptan20080096913.php Wed, 30 Apr 2008 12:37:14 -0700 Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.... http://www.freshpatents.com/Tetrahydropyridothiophenes-for-the-treatment-of-proliferative-diseases-such-as-cancer-dt20080424ptan20080096914.php Wed, 30 Apr 2008 12:37:14 -0700 in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity. Compounds of a certain formula (I),... http://www.freshpatents.com/Compositions-for-the-treatment-of-metabolic-disorders-dt20080424ptan20080096915.php Wed, 30 Apr 2008 12:37:14 -0700 Preferred embodiments of the present invention are related to novel therapeutic drugs and drug combinations, and associated methods, for treating and/or preventing complications or otherwise treating disease in patients with hypertension, diabetes, metabolic syndrome, obesity and/or other metabolic disorders.... http://www.freshpatents.com/Drugs-and-prodrugs-useful-the-treatment-of-energy-balance-in-ruminants-dt20080424ptan20080096916.php Wed, 30 Apr 2008 12:37:14 -0700 The use of a compound of formula (I) an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug, in the manufacture of a medicament for the palliative, prophylactic or curative treatment of negative energy balance in ruminants. The use... http://www.freshpatents.com/I-alkynyl-2-aryloxyalkylamides-and-their-use-as-fungicides-dt20080424ptan20080096917.php Wed, 30 Apr 2008 12:37:14 -0700 Compounds of the formula wherein the substituents are as defined in the claims, are useful as fungicides.... http://www.freshpatents.com/Novel-cyclic-ureas-used-as-inhibitors-of-metalloproteases-dt20080424ptan20080096918.php Wed, 30 Apr 2008 12:37:14 -0700 and/or all stereoisomeric forms of the compound of the formula I and/or mixtures of these forms in any ratio, and/or a physiologically tolerated salt of the compound of the formula I, in which R1 to R5 and V1, V2 have the meanings stated in the claims and specification. The inventive... http://www.freshpatents.com/Amide-derivatives-as-ion-channel-ligands-and-pharmaceutical-compositions-and-methods-of-using-the-same-dt20080424ptan20080096919.php Wed, 30 Apr 2008 12:37:14 -0700 The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others. Compounds are disclosed that have a formula represented by the following:... http://www.freshpatents.com/Farnesoid-x-receptor-agonists-dt20080424ptan20080096921.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.... http://www.freshpatents.com/Histone-deacetylase-inhibitors-dt20080424ptan20080096920.php Wed, 30 Apr 2008 12:37:14 -0700 This invention relates to iminodiacetic acid and diamine hydroxamic acid derivatives, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases, and... http://www.freshpatents.com/Novel-sulfonamide-derivative-dt20080424ptan20080096922.php Wed, 30 Apr 2008 12:37:14 -0700 or a prodrug thereof or a pharmaceutically acceptable salt of the same has an activity of potentiating an expression of a low density lipoprotein receptor and thus is useful as an agent for treating hyperlipidemia or arteriosclerosis. m, n and p is independently... http://www.freshpatents.com/Methods-for-diagnosing-and-treating-diabetic-microvascular-complications-dt20080424ptan20080096923.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to a method for treating one or more diabetic microvascular complications in a patient in need of said treatment comprising: (a) diagnosing the severity of at least three different microvascular complications in said patient by calculating a diabetes microvascular complications score with a diabetes microvascular complications... http://www.freshpatents.com/Amorphous-composition-dt20080424ptan20080096924.php Wed, 30 Apr 2008 12:37:14 -0700 To provide an amorphous composition for nasal administration or for administration by adhering to oral mucosa in which absorption property and chemical and physical stabilities of (2R)—N-(1-benzylpiperidin-4-yl)-3-cyclohexylmethylthio-2-[(4R)-3-tert-butoxycarbonylthiazolidin-4-ylcarbonylamino]propanamide which is useful as an N type calcium channel inhibitor are improved. A preparation comprising the amorphous composition of the present invention has... http://www.freshpatents.com/Novel-substituted-4-phenyl-4-h-imidazol-2-yl--piperidine-derivatived-and-their-use-as-selective-non-peptide-delta-opioid-agonists-dt20080424ptan20080096925.php Wed, 30 Apr 2008 12:37:14 -0700 the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. In particular are claimed compounds according to Formula (I) in which A=B is C═O or SO2, X is a covalent bond, R1 is alkyloxy, alkyloxyalkyl, Ar or... http://www.freshpatents.com/Treatment-of-cognitive-impairment-using-a-selective-dopamine-d1-receptor-agonist-dt20080424ptan20080096926.php Wed, 30 Apr 2008 12:37:14 -0700 Methods of using DAS-431 under conditions where it is administered at a dose that results in improved cognitive performance but without significant side effects are provided. Symptoms can be ameliorated during the period of treatment and, frequently, for substantially longer periods thereafter. In addition, the DAS-431 is provided at a... http://www.freshpatents.com/Combination-therapy-for-treating-cyclooxygenase-2-mediated-diseases-or-conditions-in-patients-at-risk-of-thrombotic-cardiovascular-events-dt20080424ptan20080096927.php Wed, 30 Apr 2008 12:37:14 -0700 The invention encompasses a pharmaceutical composition comprising a therapeutically effective amount of a cyclooxygenase-2 selective inhibitor selected from rofecoxib and etoricoxib or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of a proton pump inhibitor selected from the group consisting of: omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole, or... http://www.freshpatents.com/Methods-for-treating-hepatitis-c-dt20080424ptan20080096928.php Wed, 30 Apr 2008 12:37:14 -0700 In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the... http://www.freshpatents.com/Novel-use-dt20080424ptan20080096929.php Wed, 30 Apr 2008 12:37:14 -0700 There is disclosed the use of a compound of formula (I), (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme... http://www.freshpatents.com/Oxadiazole-ketone-inhibitors-of-fatty-acid-amide-hydrolase-dt20080424ptan20080096931.php Wed, 30 Apr 2008 12:37:14 -0700 Certain oxadiazole ketone compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat anxiety, pain, inflammation, sleep disorders, eating... http://www.freshpatents.com/Potentiators-of-glutamate-receptors-dt20080424ptan20080096930.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides compounds of formula (I); pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.... http://www.freshpatents.com/3-pyridinylethylcarboxamide--derivatives-as-fungicides-dt20080424ptan20080096932.php Wed, 30 Apr 2008 12:37:14 -0700 A method for treating plants by applying a compound of general formula (I) or a composition comprising it. A fungicidal composition comprising a compound of general formula (I). A process for preparing this compound. A compound of general formula (I):... http://www.freshpatents.com/4-pyridinylethylcarboxamide-derivatives-useful-as-fungicides-dt20080424ptan20080096933.php Wed, 30 Apr 2008 12:37:14 -0700 A method for treating plants by applying a compound of general formula (I) or a composition comprising it. A fungicidal composition comprising a compound of general formula (I). A process for preparing this compound. A compound of general formula (I):... http://www.freshpatents.com/Aminoethylaromatic-compounds-suitable-for-treating-disorders-that-respond-to-modulation-of-the-dopamine-d3-receptor-dt20080424ptan20080096934.php Wed, 30 Apr 2008 12:37:14 -0700 R6, R7 independently of each other are selected from H, fluorine, C1-C4-alkyl and fluorinated C1-C4-alkyl or together form a moiety (CH2)p with p being 2, 3, 4 or 5; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula... http://www.freshpatents.com/Heterocyclic-indanone-potentiators-of-metabotropic-glutamate-receptors-dt20080424ptan20080096935.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed... http://www.freshpatents.com/Sulfur-substituted-sulfonylaminocarboxylic-acid-n-arylamides-their-preparation-their-use-and-pharmaceutical-preparations-comprising-them-dt20080424ptan20080096936.php Wed, 30 Apr 2008 12:37:14 -0700 wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I are... http://www.freshpatents.com/Novel-hexafluoroisopropanol-derivatives-dt20080424ptan20080096937.php Wed, 30 Apr 2008 12:37:14 -0700 wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments. The invention is concerned with novel hexafluoroisopropanol derivatives of... http://www.freshpatents.com/Chemical-compounds-dt20080424ptan20080096938.php Wed, 30 Apr 2008 12:37:14 -0700 The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or S1P receptors.... http://www.freshpatents.com/5-hydroxy-benzothiazole-derivatives-having-beta-2-adrenoreceptor-agonist-activity-dt20080424ptan20080096940.php Wed, 30 Apr 2008 12:37:14 -0700 Compounds of formula (I) in free or salt or solvate form, wherein T has the meaning as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are... http://www.freshpatents.com/Process-for-preparation-of-pramipexole-by-chiral-chromatography-dt20080424ptan20080096939.php Wed, 30 Apr 2008 12:37:14 -0700 A novel process for the preparation of S(−)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexole).... http://www.freshpatents.com/Halogenated-benzamide-derivatives-dt20080424ptan20080096941.php Wed, 30 Apr 2008 12:37:14 -0700 A method of treating viral infections by the administration of a halogenated benzamide derivative according to formula (III): in which R1 is a halogen atom, and R2-R6 are independently hydrogen, hydroxyl, C1-C4 alkyl, —C1-C4 alkoxy, acyloxy, nitro, halogen, —C(O)R7 where R7 is —C1-C4 alkyl, or, aromatic including salts and hydrates... http://www.freshpatents.com/Substituted-hydroxyethylamines-dt20080424ptan20080096942.php Wed, 30 Apr 2008 12:37:14 -0700 and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R2, R4, R5, RN, and RC are defined herein. These compounds interact with and inhibit the activity of the enzyme beta-secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical... http://www.freshpatents.com/Organic-compunds-dt20080424ptan20080096943.php Wed, 30 Apr 2008 12:37:14 -0700 in free or salt form, wherein T, X, R1, R2, Ra, R3, R4, R5 and U have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3, particularly an inflammatory or allergic condition such as an inflammatory or obstructive airways disease. Pharmaceutical compositions that... http://www.freshpatents.com/Amorphous-and-crystalline-forms-of-losartan-potassium-and-process-for-their-preparation-dt20080424ptan20080096945.php Wed, 30 Apr 2008 12:37:14 -0700 This invention relates to novel amorphous losartan potassium, novel losartan potassium in a crystalline form that is a hydrate, novel crystalline losartan potassium Form IV and solvates thereof, novel crystalline losartan potassium Form V and solvates thereof, to processes for their preparation, to compositions containing them and to their use... http://www.freshpatents.com/Hydrates-of-alkaline-earth-salts-of-irbesartan-and-the-preparation-thereof-dt20080424ptan20080096944.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to hydrates of pharmaceutically acceptable alkaline-earth salts of irbesartan and to their preparation in an aqueous medium.... http://www.freshpatents.com/Process-for-the-preparation-of-anastrozole-dt20080424ptan20080096946.php Wed, 30 Apr 2008 12:37:14 -0700 A process for the preparation of anastrozole.... http://www.freshpatents.com/Parenteral-forms-of-administration-of-imexon-and-method-for-the-production-thereof-dt20080424ptan20080096947.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to intravenously highly compatible imexon injection preparations and processes for their production as well as imexon lyophilisates stable in storage for the production of the injection preparations.... http://www.freshpatents.com/Serotonin-antagonist-compositions-and-methods-for-the-local-inhibition-of-pain-and-inflammation-dt20080424ptan20080096948.php Wed, 30 Apr 2008 12:37:14 -0700 A method and solution for local inhibition of pain and inflammation by application of a serotonin antagonist, and serotonin antagonist compositions for local delivery.... http://www.freshpatents.com/Indazolyl-substituted-pyrroline-compounds-as-kinase-inhibitors-dt20080424ptan20080096949.php Wed, 30 Apr 2008 12:37:14 -0700 useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I):... http://www.freshpatents.com/Compounds-useful-in-therapy-dt20080424ptan20080096950.php Wed, 30 Apr 2008 12:37:14 -0700 and pharmaceutically acceptable salts, solvates (including hydrates) of said compounds and salts, or prodrugs of said compound, or pharmaceutically acceptable salts or solvates of said prodrugs, wherein the substituents are as herein defined, are useful in therapy, for example they may be useful for treating progesterone-mediated conditions such as endometriosis,... http://www.freshpatents.com/Carvedilol-monocitrate-monohydrate-dt20080424ptan20080096951.php Wed, 30 Apr 2008 12:37:14 -0700 This invention relates to carvedilol monocitrate monohydrate, compositions containing this salt of carvedilol and methods of using this compound to treat hypertension, congestive heart failure and angina.... http://www.freshpatents.com/Methods-for-the-treatment-of-atherosclerosis-using-substituted-phenethylsulfones-dt20080424ptan20080096952.php Wed, 30 Apr 2008 12:37:14 -0700 Methods and compositions for the prevention and treatment of all forms of atherosclerosis are described. Administration of compounds such as thalidomide, its analogs, hydrolysis products, metabolites, derivatives and precursors as well as additional compounds capable of inhibiting tumor necrosis factor α (TNF-α) are used in the invention. Also disclosed is... http://www.freshpatents.com/Vinylogous-acid-derivatives-dt20080424ptan20080096953.php Wed, 30 Apr 2008 12:37:14 -0700 wherein A and R1 to R5 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are useful as chymase inhibitors. The invention is concerned with novel vinylogous acid derivatives of formula I:... http://www.freshpatents.com/Novel-bicyclic-compounds-as-modulators-of-androgen-receptor-function-and-method-dt20080424ptan20080096954.php Wed, 30 Apr 2008 12:37:14 -0700 wherein R1, R2, R5, X and n are defined herein. There are disclosed bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia,... http://www.freshpatents.com/Histamine-3-receptor-antagonists-dt20080424ptan20080096955.php Wed, 30 Apr 2008 12:37:14 -0700 as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a process of preparation of a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering... http://www.freshpatents.com/Use-of-malonomicin-and-analogs-in-fungicidal-applications-dt20080424ptan20080096956.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention is related to the use of malonomicin compounds and derivatives in fungicidal applications and to new derivatives of malonomicin.... http://www.freshpatents.com/Albumin-binding-conjugates-comprising-a-fatty-acid-and-peg-dt20080424ptan20080096957.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding... http://www.freshpatents.com/Antibacterial-composition-dt20080424ptan20080096958.php Wed, 30 Apr 2008 12:37:14 -0700 The object of the present invention is to provide an antibacterial composition which has an improved antibacterial effect and a wider antibacterial spectrum than conventional antibacterial agents and which is highly safe. This object is achieved with an antibacterial composition comprising 9-(3′,7′-dimethyl-2′,6′-octadienyl)-4-hydroxy-7H-furo[3,2-γ][1]benzopyran-7-one and 8-(3′,7′-dimethyl-2,6′-octadienyl)-5-hydroxy-7-methoxy-2H-1-benzopyran-2-one.... http://www.freshpatents.com/Durable-biocides-and-disinfectants-dt20080424ptan20080096959.php Wed, 30 Apr 2008 12:37:14 -0700 Contemplated compositions and methods include a catechin at a concentration effective to inactivate SARS at least by a factor of 2 log 10 units when the formulation is applied to a surface. Preferably, the catechins are provided as a complex mixture, and most preferably as a near-native catechin preparation from... http://www.freshpatents.com/Acyloxyalkyl-carbamate-prodrugs-methods-of-synthesis-and-use-dt20080424ptan20080096960.php Wed, 30 Apr 2008 12:37:14 -0700 The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders... http://www.freshpatents.com/Use-of-docosatrienes-resolvins-and-their-stable-analogs-in-the-treatment-of-airway-diseases-and-asthma-dt20080424ptan20080096961.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention is generally drawn to novel isolated therapeutic agents, termed resolving, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from... http://www.freshpatents.com/Process-for-the-preparation-of-substituted-tetralin-and-substituted-indane-derivatives-dt20080424ptan20080096962.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention relates to novel processes for the preparation of substituted tetralin and substituted indane derivatives. The present invention is further directed to novel processes for the preparation of intermediates in the preparation of the substituted tetralin and substituted indane derivatives.... http://www.freshpatents.com/Use-of-a-fatty-acid-for-preparing-a-topical-composition-for-allaying-inflammatory-reaction-due-to-vennemous-hymenoptera-strings-dt20080424ptan20080096963.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to the use of a fatty acid for preparing a composition for allaying inflammatory reactions due to hypenoptera stings.... http://www.freshpatents.com/Food-fortification-with-polyunsaturated-fatty-acids-dt20080424ptan20080096964.php Wed, 30 Apr 2008 12:37:14 -0700 Coated food products fortified with a polyunsaturated fatty acid, including sweetened food products, and methods for their preparation are provided.... http://www.freshpatents.com/-halobenzyloxy--benzylamino-propanamides-as-sodium-and-or-calcium-channel-selective-modulators-dt20080424ptan20080096965.php Wed, 30 Apr 2008 12:37:14 -0700 The invention relates to the use of selected (R)-2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory... http://www.freshpatents.com/Ophthalmic-compositions-containing-diglycine-dt20080424ptan20080096966.php Wed, 30 Apr 2008 12:37:14 -0700 Ophthalmic composition comprising one or more polyglycines selected from the group consisting of diglycine, triglycine, tetraglycine and pentaglycine, or the salts of each thereof and one or more boron buffering compounds. The ophthalmic composition will have an osmolality of from 200 mOsmol/kg to 420 mOsmol/kg.... http://www.freshpatents.com/Formulations-for-injection-of-catecholic-butanes-including-ndga-compounds-into-animals-dt20080424ptan20080096967.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides for a composition, kit and method for treatment of diseases, where the composition contains at least one catecholic butane, including NDGA compounds and derivatives, together with a pharmaceutically acceptable carrier that may include solubilizing agents or excipients, where the composition is suitable for injection into animals.... http://www.freshpatents.com/Derivatives-of-1-phenylalkanecarboxylic-acids-for-the-treatment-of-neurodegenerative-diseases-dt20080424ptan20080096968.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids, pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer' s disease.... http://www.freshpatents.com/N-alpha--menthanecarbonyl-amino-acid-amides-and-use-thereof-as-physiological-cooling-active-ingredients-dt20080424ptan20080096969.php Wed, 30 Apr 2008 12:37:14 -0700 and mixtures thereof and to the use of the specific Nα-(menthanecarbonyl)amino acid amides and mixtures thereof as physiological cooling active ingredients. The present invention relates to specific Nα-(menthanecarbonyl)amino acid amides of the formula (I):... http://www.freshpatents.com/Stable-nateglinide-form-b-compositions-dt20080424ptan20080096970.php Wed, 30 Apr 2008 12:37:14 -0700 A process for preparing nateglinide Form B comprises dissolving nateglinide in a solvent and adding the solution, at temperatures of 40-45° C., to a hydrocarbon liquid that is at temperatures of 40-45° C. Then, water is added and the mixture is allowed to cool, producing crystals of nateglinide Form B.... http://www.freshpatents.com/Treatment-of-inflammatory-disorders-and-pain-dt20080424ptan20080096971.php Wed, 30 Apr 2008 12:37:14 -0700 wherein R1 is CHR4—OR5 or CHR4—SR5, or aryl or heteroaryl optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is... http://www.freshpatents.com/Compound-formulations-of-2-amino-1-3-propanediol-compounds-dt20080424ptan20080096972.php Wed, 30 Apr 2008 12:37:14 -0700 Pharmaceutical concentrate formulations comprising 2-amino-1,3-propanediol compounds, analogs thereof and salts thereof, particularly 2-amino-2-[2-(4-octylphenyl)ethyl]-propane-1,3-diol or a pharmaceutically acceptable salt thereof in an organic solvent or semi-aqueous solvent and methods for administration of the undiluted and diluted concentrate are provided.... http://www.freshpatents.com/Z-stilbenes-derivatives-and-the-pharmaceutical-composition-thereof-dt20080424ptan20080096973.php Wed, 30 Apr 2008 12:37:14 -0700 A series of Z-stilbenes derivatives are disclosed, which have the structure as shown by formula 1. In the structure of formula 1, X is hydrogen, NHR, or nitro group, and R is hydrogen. Y and Z is independently hydrogen, halogen, C1-C10 alkyl, or C1-C10 alkoxyl. Furthermore, A is hydrogen, hydroxyl,... http://www.freshpatents.com/Polyamine-metal-chelator-conjugates-dt20080424ptan20080096974.php Wed, 30 Apr 2008 12:37:14 -0700 Many metal chelators have polar or charged functional groups, which render them difficult to transport across a cell membrane. Polyamine-metal chelator conjugates of the invention are compounds comprising a first moiety which is a metal chelator and a second moiety which is a polyamine, where the polyamine moiety includes three... http://www.freshpatents.com/Method-of-treating-spinal-internal-disk-derangement-dt20080424ptan20080096976.php Wed, 30 Apr 2008 12:37:14 -0700 A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles. The bulking agent results in at least one of sealing the defect, increasing a... http://www.freshpatents.com/Thermoresponsive-biodegradable-elastomeric-material-dt20080424ptan20080096975.php Wed, 30 Apr 2008 12:37:14 -0700 Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example... http://www.freshpatents.com/Biocompatible-phase-invertable-proteinaceous-compositions-and-methods-for-making-and-using-the-same-dt20080424ptan20080096977.php Wed, 30 Apr 2008 12:37:14 -0700 Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross-linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of:... http://www.freshpatents.com/Ophthalmic-solutions-dt20080424ptan20080096978.php Wed, 30 Apr 2008 12:37:14 -0700 An ophthalmic solution comprising a hydrogen peroxide source in an amount sufficient to result in between about 0.001% and about 0.01% by weight stabilized hydrogen peroxide in said formulation as a preservative, one or more ocularly-compatible hydrogen peroxide stabilizers, hydroxypropylmethylcellulose and sodium carboxymethylcellulose, as well as pharmaceutical compositions comprising such... http://www.freshpatents.com/Aqueous-pharmaceutical-coating-dt20080424ptan20080096979.php Wed, 30 Apr 2008 12:37:14 -0700 Novel, stable aqueous coating dispersions of wax or combination of waxes are described. The composition apart from wax includes an emulsifier and a plasticizer. The pharmaceutical applications of the dispersion include taste masking, stabilization and release retardation of drugs.... http://www.freshpatents.com/Methods-and-compositions-for-reducing-a-level-of-a-toxic-protein-in-a-cell-dt20080424ptan20080096980.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention provides a method of reducing a level of a toxic protein in the cytosol of a cell, the method generally involving contacting the cell with an agent that induces a survival response by the cell. The present invention provides a method of reducing a level of a... http://www.freshpatents.com/Antibodies-against-inducible-th2-cell-factors-dt20080424ptan20080096981.php Wed, 30 Apr 2008 12:37:14 -0700 A novel TH2 associated gene that is induced by IL-9 has been identified and isolated, thereby providing a therapeutic target for IL-9 mediated diseases such as atopic allergy and asthma-related disorders. The invention also includes methods for the identification and use of small molecule inhibitors of this gene and its... http://www.freshpatents.com/Methods-for-treatment-with-bucindolol-based-on-genetic-targeting-dt20080424ptan20080096982.php Wed, 30 Apr 2008 12:37:14 -0700 The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the Arg 389 polymorphism in the β1-adrenergic receptor...